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10.1128/MCB.00677-15 http://scihub22266oqcxt.onion/10.1128/MCB.00677-15 C4609743!4609743 !26324324     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26324324 &cmd=llinks): Failed to open stream: HTTP request failed! 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Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes |pdf=|usr=}}{{26324324 }} gab.com Text Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26324324 #FOAvip Trithorax group (TrxG) and Polycomb group (PcG) proteins are two mutually antagonistic chromatin modifying complexes, however, how they together mediate transcriptional counter-regulation remains unknown. Genome-wide analysis revealed that binding of Ezh2 and menin, central members of the PcG and TrxG complexes, respectively, were reciprocally correlated. Moreover, we identified a developmental change in the positioning of Ezh2 and menin in differentiated T lymphocytes compared to embryonic stem cells. Ezh2-binding upstream and menin-binding downstream of the transcription start site was frequently found at genes with higher transcriptional levels, and Ezh2-binding downstream and menin-binding upstream was found at genes with lower expression in T lymphocytes. Interestingly, of the Ezh2 and menin cooccupied genes, those exhibiting occupancy at the same position displayed greatly enhanced sensitivity to loss of Ezh2. Finally, we also found that different combinations of Ezh2 and menin occupancy were associated with expression of specific functional gene groups important for T cell development. Therefore, spatial cooperative gene regulation by the PcG and TrxG complexes may represent a novel mechanism regulating the transcriptional identity of differentiated cells. Twit Text FOAVip Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26324324 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26324324 #FOAvip English Wikipedia <ref>{{Cite pmid|26324324 }}</ref> Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes #MMPMID26324324 Onodera A ; Tumes DJ ; Watanabe Y ; Hirahara K ; Kaneda A ; Sugiyama F ; Suzuki Y ; Nakayama T Mol Cell Biol 2015[Nov]; 35 (22 ): 3841-53 PMID26324324 show ga Trithorax group (TrxG) and Polycomb group (PcG) proteins are two mutually antagonistic chromatin modifying complexes, however, how they together mediate transcriptional counter-regulation remains unknown. Genome-wide analysis revealed that binding of Ezh2 and menin, central members of the PcG and TrxG complexes, respectively, were reciprocally correlated. Moreover, we identified a developmental change in the positioning of Ezh2 and menin in differentiated T lymphocytes compared to embryonic stem cells. Ezh2-binding upstream and menin-binding downstream of the transcription start site was frequently found at genes with higher transcriptional levels, and Ezh2-binding downstream and menin-binding upstream was found at genes with lower expression in T lymphocytes. Interestingly, of the Ezh2 and menin cooccupied genes, those exhibiting occupancy at the same position displayed greatly enhanced sensitivity to loss of Ezh2. Finally, we also found that different combinations of Ezh2 and menin occupancy were associated with expression of specific functional gene groups important for T cell development. Therefore, spatial cooperative gene regulation by the PcG and TrxG complexes may represent a novel mechanism regulating the transcriptional identity of differentiated cells. |*Transcriptional Activation [MESH] |Animals [MESH] |B-Lymphocytes/metabolism [MESH] |Cell Line [MESH] |Cells, Cultured [MESH] |Embryonic Stem Cells/metabolism [MESH] |Enhancer of Zeste Homolog 2 Protein [MESH] |Genome [MESH] |Mice, Inbred C57BL [MESH] |Polycomb Repressive Complex 2/*metabolism [MESH] |Protein Binding [MESH] |Proto-Oncogene Proteins/*metabolism [MESH] |T-Lymphocytes/cytology/*metabolism [MESH]Spatial Interplay between Polycomb and Trithorax Complexes Controls (epmc).pdf DeepDyve Pubget Overpricing