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10.1016/j.neurobiolaging.2015.07.016 http://scihub22266oqcxt.onion/10.1016/j.neurobiolaging.2015.07.016 C4609585!4609585 !26248866     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26248866 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neurobiol+Aging 2015 ; 36 (11 ): 2963-2971 Nephropedia Template TP {{tp|p=26248866 |t=2015. Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy |pdf=|usr=}}{{26248866 }} gab.com Text Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy JO: Neurobiol Aging http://www.kidney.de/pget.php?&tw=1&pmid=26248866 #FOAvip Cerebral amyloid angiopathy (CAA), the deposition of amyloid-? in cerebrovascular walls, is the most common cause of lobar hemorrhagic stroke. Previous studies show that cerebrovascular amyloid-? induces expression and activation of matrix metalloproteinase 9 (MMP-9) in cerebral vessels of amyloid precursor protein transgenic mice. Here, we extended these findings and evaluated MMP-9 expression in postmortem brain tissues of human CAA cases. MMP-9 colocalized with CAA, correlated with the severity of the vascular pathology, and was detected in proximity to microbleeds. We characterized a novel assay using longitudinal multiphoton microscopy and a novel tracer to visualize and quantify the magnitude and kinetics of hemorrhages in three dimensions in living mouse brains. We demonstrated that topical application of recombinant MMP-9 resulted in a time- and dose-dependent cerebral hemorrhage. Amyloid precursor protein mice with significant CAA developed more extensive hemorrhages which also appeared sooner after exposure to MMP-9. Our data suggest an important role for MMP-9 in development of hemorrhages in the setting of CAA. Inhibition of MMP-9 may present a preventive strategy for CAA-associated hemorrhage. Twit Text FOAVip Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy ????Neurobiol Aging http://www.kidney.de/pget.php?&tw=1&pmid=26248866 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26248866 #FOAvip English Wikipedia <ref>{{Cite pmid|26248866 }}</ref> Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy #MMPMID26248866 Zhao L ; Arbel-Ornath M ; Wang X ; Betensky RA ; Greenberg SM ; Frosch MP ; Bacskai BJ Neurobiol Aging 2015[Nov]; 36 (11 ): 2963-2971 PMID26248866 show ga Cerebral amyloid angiopathy (CAA), the deposition of amyloid-? in cerebrovascular walls, is the most common cause of lobar hemorrhagic stroke. Previous studies show that cerebrovascular amyloid-? induces expression and activation of matrix metalloproteinase 9 (MMP-9) in cerebral vessels of amyloid precursor protein transgenic mice. Here, we extended these findings and evaluated MMP-9 expression in postmortem brain tissues of human CAA cases. MMP-9 colocalized with CAA, correlated with the severity of the vascular pathology, and was detected in proximity to microbleeds. We characterized a novel assay using longitudinal multiphoton microscopy and a novel tracer to visualize and quantify the magnitude and kinetics of hemorrhages in three dimensions in living mouse brains. We demonstrated that topical application of recombinant MMP-9 resulted in a time- and dose-dependent cerebral hemorrhage. Amyloid precursor protein mice with significant CAA developed more extensive hemorrhages which also appeared sooner after exposure to MMP-9. Our data suggest an important role for MMP-9 in development of hemorrhages in the setting of CAA. Inhibition of MMP-9 may present a preventive strategy for CAA-associated hemorrhage. |Aged [MESH] |Aged, 80 and over [MESH] |Amyloid beta-Peptides/metabolism [MESH] |Animals [MESH] |Cerebral Amyloid Angiopathy/*complications/*genetics/metabolism [MESH] |Cerebral Hemorrhage/*etiology/*genetics/metabolism/prevention & control [MESH] |Dose-Response Relationship, Drug [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Matrix Metalloproteinase 9/*metabolism/pharmacology [MESH] |Mice, Inbred C57BL [MESH] |Microscopy, Fluorescence, Multiphoton [MESH] |Middle Aged [MESH] |Molecular Targeted Therapy [MESH] |Recombinant Proteins/pharmacology [MESH]Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced b(epmc).pdf DeepDyve Pubget Overpricing