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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Immunol+Res
2015 ; 2015
(ä): 380975
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
FluKB: A Knowledge-Based System for Influenza Vaccine Target Discovery and
Analysis of the Immunological Properties of Influenza Viruses
#MMPMID26504853
Simon C
; Kudahl UJ
; Sun J
; Olsen LR
; Zhang GL
; Reinherz EL
; Brusic V
J Immunol Res
2015[]; 2015
(ä): 380975
PMID26504853
show ga
FluKB is a knowledge-based system focusing on data and analytical tools for
influenza vaccine discovery. The main goal of FluKB is to provide access to
curated influenza sequence and epitope data and enhance the analysis of influenza
sequence diversity and the analysis of targets of immune responses. FluKB
consists of more than 400,000 influenza protein sequences, known epitope data
(357 verified T-cell epitopes, 685 HLA binders, and 16 naturally processed MHC
ligands), and a collection of 28 influenza antibodies and their structurally
defined B-cell epitopes. FluKB was built using a modular framework allowing the
implementation of analytical workflows and includes standard search tools, such
as keyword search and sequence similarity queries, as well as advanced tools for
the analysis of sequence variability. The advanced analytical tools for vaccine
discovery include visual mapping of T- and B-cell vaccine targets and assessment
of neutralizing antibody coverage. FluKB supports the discovery of vaccine
targets and the analysis of viral diversity and its implications for vaccine
discovery as well as potential T-cell breadth and antibody cross neutralization
involving multiple strains. FluKB is representation of a new generation of
databases that integrates data, analytical tools, and analytical workflows that
enable comprehensive analysis and automatic generation of analysis reports.