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10.1212/NXI.0000000000000165

http://scihub22266oqcxt.onion/10.1212/NXI.0000000000000165
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C4608757!4608757 !26516630
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suck abstract from ncbi


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pmid26516630
      Neurol+Neuroimmunol+Neuroinflamm 2015 ; 2 (6 ): e165
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  • Reduction of microbleeds by immunosuppression in a patient with A?-related vascular inflammation #MMPMID26516630
  • Traschütz A ; Tzaridis T ; Penner AH ; Kuchelmeister K ; Urbach H ; Hattingen E ; Heneka MT
  • Neurol Neuroimmunol Neuroinflamm 2015[Dec]; 2 (6 ): e165 PMID26516630 show ga
  • OBJECTIVE: To investigate whether the occurrence or clearance of microhemorrhages in cerebral amyloid angiopathy (CAA)-related vascular inflammation can be modified by immunosuppressive treatment. METHODS: Clinical and radiologic follow-up for more than 5 years of a patient with histopathologically confirmed CAA-related vascular inflammation treated with a prolonged and tapered regimen of IV cyclophosphamide and oral steroids. RESULTS: Under long-term immunosuppressive treatment, a reduced number of cortical micobleeds was observed on repeat MRIs because of both the prevention of new microbleeds and the clearance of those existing at baseline. CONCLUSIONS: Sustained immunosuppression should be considered and systematically investigated as a treatment option for cortical microbleeds in CAA and related inflammatory phenotypes. CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence. This is a single observational study without controls.
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