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10.1371/journal.pone.0140624 http://scihub22266oqcxt.onion/10.1371/journal.pone.0140624 C4608716!4608716 !26473361     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26473361 &cmd=llinks): Failed to open stream: HTTP request failed! 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Progesterone for Acute Traumatic Brain Injury: A Systematic Review of Randomized Controlled Trials |pdf=|usr=}}{{26473361 }} gab.com Text Progesterone for Acute Traumatic Brain Injury: A Systematic Review of Randomized Controlled Trials JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26473361 #FOAvip OBJECTIVE: To evaluate the efficacy and safety of progesterone administrated in patients with acute traumatic brain injury (TBI). METHODS: PubMed/MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Clinicaltrials.gov, ISRCTN registry and WHO International Clinical Trials Registry Platform (ICTRP) were searched for randomized controlled trials (RCTs) comparing progesterone and placebo administrated in acute TBI patients. The primary outcome was mortality and the secondary outcomes were unfavorable outcomes and adverse events. A meta-analysis was conducted to evaluate the efficacy and safety of progesterone administrated in patients with acute TBI. RESULTS: A total of 6 studies met inclusion criteria, involving 2,476 patients. The risk of bias was considered to be low in 4 studies but high in the other 2 studies. The results of meta-analysis indicated progesterone did not reduce the mortality (RR = 0.83, 95% CI = 0.57-1.20) or unfavorable outcomes (RR = 0.89, 95% CI = 0.78-1.02) of acute TBI patients in comparison with placebo. Sensitivity analysis yielded consistent results. Progesterone was basically safe and well tolerated in TBI patients with the exception of increased risk of phlebitis or thrombophlebitis (RR = 3.03, 95% CI = 1.96-4.66). CONCLUSIONS: Despite some modest bias, present evidence demonstrated that progesterone was well tolerated but did not reduce the mortality or unfavorable outcomes of adult patients with acute TBI. Twit Text FOAVip Progesterone for Acute Traumatic Brain Injury: A Systematic Review of Randomized Controlled Trials ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26473361 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26473361 #FOAvip English Wikipedia <ref>{{Cite pmid|26473361 }}</ref> Progesterone for Acute Traumatic Brain Injury: A Systematic Review of Randomized Controlled Trials #MMPMID26473361 Zeng Y ; Zhang Y ; Ma J ; Xu J PLoS One 2015[]; 10 (10 ): e0140624 PMID26473361 show ga OBJECTIVE: To evaluate the efficacy and safety of progesterone administrated in patients with acute traumatic brain injury (TBI). METHODS: PubMed/MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Clinicaltrials.gov, ISRCTN registry and WHO International Clinical Trials Registry Platform (ICTRP) were searched for randomized controlled trials (RCTs) comparing progesterone and placebo administrated in acute TBI patients. The primary outcome was mortality and the secondary outcomes were unfavorable outcomes and adverse events. A meta-analysis was conducted to evaluate the efficacy and safety of progesterone administrated in patients with acute TBI. RESULTS: A total of 6 studies met inclusion criteria, involving 2,476 patients. The risk of bias was considered to be low in 4 studies but high in the other 2 studies. The results of meta-analysis indicated progesterone did not reduce the mortality (RR = 0.83, 95% CI = 0.57-1.20) or unfavorable outcomes (RR = 0.89, 95% CI = 0.78-1.02) of acute TBI patients in comparison with placebo. Sensitivity analysis yielded consistent results. Progesterone was basically safe and well tolerated in TBI patients with the exception of increased risk of phlebitis or thrombophlebitis (RR = 3.03, 95% CI = 1.96-4.66). CONCLUSIONS: Despite some modest bias, present evidence demonstrated that progesterone was well tolerated but did not reduce the mortality or unfavorable outcomes of adult patients with acute TBI. |Brain Injuries/*drug therapy [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Progesterone/*administration & dosage/adverse effects [MESH] |Randomized Controlled Trials as Topic [MESH] |Survival Analysis [MESH]Progesterone for Acute Traumatic Brain Injury: A Systematic Review of (epmc).pdf DeepDyve Pubget Overpricing