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10.1111/cei.12681

http://scihub22266oqcxt.onion/10.1111/cei.12681
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C4608509!4608509!26178578
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suck abstract from ncbi


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pmid26178578      Clin+Exp+Immunol 2015 ; 182 (2): 195-203
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  • Human norovirus infection and the acute serum cytokine response #MMPMID26178578
  • Newman KL; Moe CL; Kirby AE; Flanders WD; Parkos CA; Leon JS
  • Clin Exp Immunol 2015[Nov]; 182 (2): 195-203 PMID26178578show ga
  • Noroviruses (NoV) are the most common cause of epidemic gastroenteritis worldwide. The acute immune response to NoV in humans is poorly understood, hindering research on prevention and treatment. To elucidate the acute immune response and test for cytokine predictors of susceptibility to infection, serum samples from two human NoV challenge studies were tested for 16 cytokines. Subjects who became infected (n?=?26) were age-matched with subjects who remained uninfected following NoV challenge (n?=?26). Samples were tested from prechallenge and days 1-4 post-challenge. Cytokine responses were compared between infected and uninfected groups. Overall, infected individuals exhibited an elevation in T helper type 1 (Th1) and Th2 cytokines, as well as chemokines interleukin (IL)-8 and monocyte chemoattractant protein (MCP-1), compared to uninfected individuals (all P?
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