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2015 ; 182
(2
): 184-94
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Expression of CD11c and EMR2 on neutrophils: potential diagnostic biomarkers for
sepsis and systemic inflammation
#MMPMID26153037
Lewis SM
; Treacher DF
; Edgeworth J
; Mahalingam G
; Brown CS
; Mare TA
; Stacey M
; Beale R
; Brown KA
Clin Exp Immunol
2015[Nov]; 182
(2
): 184-94
PMID26153037
show ga
There is a need for cellular biomarkers to differentiate patients with sepsis
from those with the non-infectious systemic inflammatory response syndrome
(SIRS). In this double-blind study we determined whether the expression of known
(CD11a/b/c, CD62L) and putative adhesion molecules [CD64, CD97 and epidermal
growth factor (EGF)-like molecule containing mucin-like hormone receptor (EMR2)]
on blood neutrophils could serve as useful biomarkers of infection and of
non-infectious SIRS in critically ill patients. We studied 103 patients with
SIRS, 83 of whom had sepsis, and 50 healthy normal subjects, using flow cytometry
to characterize neutrophils phenotypically in whole blood samples. Patients with
SIRS had an increased prevalence of neutrophils expressing CD11c, CD64 and EMR2
in comparison with healthy subjects (P < 0.001), but normal expression of CD11a,
CD11b, CD62L and CD97. An increase in the percentage of neutrophils bearing CD11c
was associated with sepsis, EMR2 with SIRS and CD64 with sepsis and SIRS.
Neutrophils expressing CD11c had the highest sensitivity (81%) and specificity
(80%) for the detection of sepsis, and there was an association between the
percentage of neutrophils expressing EMR2 and the extent of organ failure (P <
0.05). Contrary to other reports, we did not observe an abnormal expression of
CD11b or CD62L on neutrophils from patients with SIRS, and suggest that this
discrepancy is due to differences in cell processing protocols. We propose that
blood neutrophils expressing CD11c and EMR2 be considered as potential biomarkers
for sepsis and SIRS, respectively.
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