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10.1182/blood-2015-04-637702 http://scihub22266oqcxt.onion/10.1182/blood-2015-04-637702 C4608391!4608391 !26276668     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26276668 &cmd=llinks): Failed to open stream: HTTP request failed! 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Autophagic vesicles on mature human reticulocytes explain phosphatidylserine-positive red cells in sickle cell disease |pdf=|usr=}}{{26276668 }} gab.com Text Autophagic vesicles on mature human reticulocytes explain phosphatidylserine-positive red cells in sickle cell disease JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=26276668 #FOAvip During maturation to an erythrocyte, a reticulocyte must eliminate any residual organelles and reduce its surface area and volume. Here we show this involves a novel process whereby large, intact, inside-out phosphatidylserine (PS)-exposed autophagic vesicles are extruded. Cell surface PS is a well-characterized apoptotic signal initiating phagocytosis. In peripheral blood from patients after splenectomy or in patients with sickle cell disease (SCD), the number of circulating red cells exposing PS on their surface is elevated. We show that in these patients PS is present on the cell surface of red cells in large (?1.4 µm) discrete areas corresponding to autophagic vesicles. The autophagic vesicles found on reticulocytes are identical to those observed on red cells from splenectomized individuals and patients with SCD. Our data suggest the increased thrombotic risk associated with splenectomy, and patients with hemoglobinopathies is a possible consequence of increased levels of circulating mature reticulocytes expressing inside-out PS-exposed autophagic vesicles because of asplenia. Twit Text FOAVip Autophagic vesicles on mature human reticulocytes explain phosphatidylserine-positive red cells in sickle cell disease ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=26276668 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26276668 #FOAvip English Wikipedia <ref>{{Cite pmid|26276668 }}</ref> Autophagic vesicles on mature human reticulocytes explain phosphatidylserine-positive red cells in sickle cell disease #MMPMID26276668 Mankelow TJ ; Griffiths RE ; Trompeter S ; Flatt JF ; Cogan NM ; Massey EJ ; Anstee DJ Blood 2015[Oct]; 126 (15 ): 1831-4 PMID26276668 show ga During maturation to an erythrocyte, a reticulocyte must eliminate any residual organelles and reduce its surface area and volume. Here we show this involves a novel process whereby large, intact, inside-out phosphatidylserine (PS)-exposed autophagic vesicles are extruded. Cell surface PS is a well-characterized apoptotic signal initiating phagocytosis. In peripheral blood from patients after splenectomy or in patients with sickle cell disease (SCD), the number of circulating red cells exposing PS on their surface is elevated. We show that in these patients PS is present on the cell surface of red cells in large (?1.4 µm) discrete areas corresponding to autophagic vesicles. The autophagic vesicles found on reticulocytes are identical to those observed on red cells from splenectomized individuals and patients with SCD. Our data suggest the increased thrombotic risk associated with splenectomy, and patients with hemoglobinopathies is a possible consequence of increased levels of circulating mature reticulocytes expressing inside-out PS-exposed autophagic vesicles because of asplenia. |*Autophagy [MESH] |Anemia, Sickle Cell/*blood/*pathology [MESH] |Blotting, Western [MESH] |Case-Control Studies [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Erythrocytes/metabolism/*pathology [MESH] |Flow Cytometry [MESH] |Glycophorins/metabolism [MESH] |Humans [MESH] |Image Processing, Computer-Assisted [MESH] |Phagocytosis [MESH] |Phosphatidylserines/chemistry/*metabolism [MESH] |Reticulocytes/metabolism/*pathology [MESH]Autophagic vesicles on mature human reticulocytes explain phosphatid(epmc).pdf DeepDyve Pubget Overpricing