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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Obstet+Gynecol
2012 ; 119
(5
): 1009-16
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Chlamydia trachomatis antigens recognized in women with tubal factor infertility,
normal fertility, and acute infection
#MMPMID22525912
Budrys NM
; Gong S
; Rodgers AK
; Wang J
; Louden C
; Shain R
; Schenken RS
; Zhong G
Obstet Gynecol
2012[May]; 119
(5
): 1009-16
PMID22525912
show ga
OBJECTIVE: To identify Chlamydia trachomatis antigens associated with tubal
factor infertility and acute infection. METHODS: A C trachomatis proteome array
was used to compare antibody profiles among women with tubal factor infertility,
normal fertility, and acute C trachomatis infection. RESULTS: Thirteen
immunodominant antigens reacted with 50% or more sera from all women (n=73). Six
C trachomatis antigens were uniquely recognized in women with tubal factor
infertility. Combining fragmentation of the six antigens with serum sample
dilution, chlamydial antigens HSP60, CT376, CT557, and CT443 could discriminate
between women with tubal factor infertility and women with normal fertility with
a sensitivity of 63% (95% confidence interval [CI] 0.41-0.77) and specificity of
100% (95% CI 0.91-1), respectively. These antigens were designated as tubal
factor infertility-associated antigens. However, these tubal factor antigens were
unable to distinguish tubal factor infertility patients from those with acute
infection. A combination of CT875 and CT147 distinguished women with acute
infection from all other C trachomatis-exposed women with a detection sensitivity
of 63% (95% CI 0.41-0.77) and specificity of 100% (95% CI 0.95-1), respectively.
Thus, CT875 and CT147 were designated as acute infection-associated antigens.
CONCLUSION: A sequential screening of antibodies against panels of C trachomatis
antigens can be used to identify women with tubal factor infertility and acute C
trachomatis infection. LEVEL OF EVIDENCE: II.