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10.1097/AOG.0b013e3182519326

http://scihub22266oqcxt.onion/10.1097/AOG.0b013e3182519326
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C4608258!4608258 !22525912
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suck abstract from ncbi


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pmid22525912
      Obstet+Gynecol 2012 ; 119 (5 ): 1009-16
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  • Chlamydia trachomatis antigens recognized in women with tubal factor infertility, normal fertility, and acute infection #MMPMID22525912
  • Budrys NM ; Gong S ; Rodgers AK ; Wang J ; Louden C ; Shain R ; Schenken RS ; Zhong G
  • Obstet Gynecol 2012[May]; 119 (5 ): 1009-16 PMID22525912 show ga
  • OBJECTIVE: To identify Chlamydia trachomatis antigens associated with tubal factor infertility and acute infection. METHODS: A C trachomatis proteome array was used to compare antibody profiles among women with tubal factor infertility, normal fertility, and acute C trachomatis infection. RESULTS: Thirteen immunodominant antigens reacted with 50% or more sera from all women (n=73). Six C trachomatis antigens were uniquely recognized in women with tubal factor infertility. Combining fragmentation of the six antigens with serum sample dilution, chlamydial antigens HSP60, CT376, CT557, and CT443 could discriminate between women with tubal factor infertility and women with normal fertility with a sensitivity of 63% (95% confidence interval [CI] 0.41-0.77) and specificity of 100% (95% CI 0.91-1), respectively. These antigens were designated as tubal factor infertility-associated antigens. However, these tubal factor antigens were unable to distinguish tubal factor infertility patients from those with acute infection. A combination of CT875 and CT147 distinguished women with acute infection from all other C trachomatis-exposed women with a detection sensitivity of 63% (95% CI 0.41-0.77) and specificity of 100% (95% CI 0.95-1), respectively. Thus, CT875 and CT147 were designated as acute infection-associated antigens. CONCLUSION: A sequential screening of antibodies against panels of C trachomatis antigens can be used to identify women with tubal factor infertility and acute C trachomatis infection. LEVEL OF EVIDENCE: II.
  • |*Antigens, Bacterial [MESH]
  • |*Bacterial Proteins [MESH]
  • |Acute Disease [MESH]
  • |Adult [MESH]
  • |Antibodies, Bacterial/*blood [MESH]
  • |Biomarkers/blood [MESH]
  • |Chlamydia Infections/blood/*diagnosis/microbiology [MESH]
  • |Chlamydia trachomatis/*immunology [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Infertility, Female/blood/*diagnosis/microbiology [MESH]
  • |Protein Array Analysis [MESH]
  • |Proteome [MESH]


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