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10.1038/srep15192 http://scihub22266oqcxt.onion/10.1038/srep15192 C4608009!4608009 !26471474     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26471474 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 15192 Nephropedia Template TP {{tp|p=26471474 |t=2015. Mass Spectrometric and Spectrofluorometric Studies of the Interaction of Aristolochic Acids with Proteins |pdf=|usr=}}{{26471474 }} gab.com Text Mass Spectrometric and Spectrofluorometric Studies of the Interaction of Aristolochic Acids with Proteins JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26471474 #FOAvip Aristolochic acid (AA) is a potent carcinogen and nephrotoxin and is associated with the development of "Chinese herb nephropathy" and Balkan endemic nephropathy. Despite decades of research, the specific mechanism of the observed nephrotoxicity has remained elusive and the potential effects on proteins due to the observed toxicity of AA are not well-understood. To better understand the pharmacotoxicological features of AA, we investigated the non-covalent interactions of AA with proteins. The protein-binding properties of AA with bovine serum albumin (BSA) and lysozyme were characterized using spectrofluorometric and mass spectrometric (MS) techniques. Moreover, the protein-AA complexes were clearly identified by high-resolution MS analyses. To the best of our knowledge, this is the first direct evidence of non-covalently bound protein-AA complexes. An analysis of the spectrofluorometric data by a modified Stern-Volmer plot model also revealed that both aristolochic acid I (AAI) and aristolochic acid II (AAII) were bound to BSA and lysozyme in 1:1 stoichiometries. A significantly stronger protein binding property was observed in AAII than in AAI as evidenced by the spectrofluorometric and MS analyses, which may explain the observed higher mutagenicity of AAII. Twit Text FOAVip Mass Spectrometric and Spectrofluorometric Studies of the Interaction of Aristolochic Acids with Proteins ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26471474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26471474 #FOAvip English Wikipedia <ref>{{Cite pmid|26471474 }}</ref> Mass Spectrometric and Spectrofluorometric Studies of the Interaction of Aristolochic Acids with Proteins #MMPMID26471474 Li W ; Hu Q ; Chan W Sci Rep 2015[Oct]; 5 (ä): 15192 PMID26471474 show ga Aristolochic acid (AA) is a potent carcinogen and nephrotoxin and is associated with the development of "Chinese herb nephropathy" and Balkan endemic nephropathy. Despite decades of research, the specific mechanism of the observed nephrotoxicity has remained elusive and the potential effects on proteins due to the observed toxicity of AA are not well-understood. To better understand the pharmacotoxicological features of AA, we investigated the non-covalent interactions of AA with proteins. The protein-binding properties of AA with bovine serum albumin (BSA) and lysozyme were characterized using spectrofluorometric and mass spectrometric (MS) techniques. Moreover, the protein-AA complexes were clearly identified by high-resolution MS analyses. To the best of our knowledge, this is the first direct evidence of non-covalently bound protein-AA complexes. An analysis of the spectrofluorometric data by a modified Stern-Volmer plot model also revealed that both aristolochic acid I (AAI) and aristolochic acid II (AAII) were bound to BSA and lysozyme in 1:1 stoichiometries. A significantly stronger protein binding property was observed in AAII than in AAI as evidenced by the spectrofluorometric and MS analyses, which may explain the observed higher mutagenicity of AAII. |Animals [MESH] |Aristolochic Acids/*chemistry/metabolism [MESH] |Cattle [MESH] |Muramidase/*chemistry/metabolism [MESH] |Protein Binding [MESH] |Serum Albumin, Bovine/*chemistry/metabolism [MESH] |Spectrometry, Fluorescence [MESH]Mass Spectrometric and Spectrofluorometric Studies of the Interaction (epmc).pdf DeepDyve Pubget Overpricing