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10.1038/srep15242

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suck abstract from ncbi


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pmid26472621
      Sci+Rep 2015 ; 5 (ä): 15242
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  • Microscopic Haematuria and Clinical Outcomes in Patients With Stage 3-5 Nondiabetic Chronic Kidney Disease #MMPMID26472621
  • You-Hsien Lin H ; Yen CY ; Lim LM ; Hwang DY ; Tsai JC ; Hwang SJ ; Hung CC ; Chen HC
  • Sci Rep 2015[Oct]; 5 (ä): 15242 PMID26472621 show ga
  • Microscopic haematuria is proposed as a prognostic factor for renal outcomes in patients with glomerulonephritis. However, the role of haematuria in patients with advanced chronic kidney disease (CKD) or heavy proteinuria has not been investigated. We divided 1799 patients with stage 3-5 nondiabetic CKD into 3 groups according to the results from 3 urinalyses: no haematuria (0-2 red blood cells [RBCs]/hpf ?2 times), mild haematuria (2-5 RBCs/hpf ?2 times) and moderate haematuria (?5-10?RBCs/hpf ?2 times). The estimated glomerular filtration rate was 25.4?mL/min/1.73?m(2), with a urine protein-to-creatinine ratio (UPCR) of 881?mg/g. The hazard ratios (HRs) of mild and moderate haematuria for end-stage renal disease (ESRD) were 1.28 (95% confidence interval [CI]: 1.05-1.56, P?=?0.024) and 1.34 (95% CI: 1.03-1.74, P?=?0.030), respectively. The HR of moderate haematuria for mortality was 1.56 (95% CI: 1.11-2.20, P?=?0.011). According to subgroup analysis, the HR of moderate haematuria for ESRD in patients with a UPCR of <500?mg/g was more prominent than that in patients with a UPCR of ?500?mg/g. Microscopic haematuria in patients with stage 3-5 nondiabetic CKD is associated with increased risks of ESRD and mortality.
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Cardiovascular Diseases/etiology [MESH]
  • |Creatinine/urine [MESH]
  • |Disease Progression [MESH]
  • |Erythrocytes/cytology [MESH]
  • |Female [MESH]
  • |Follow-Up Studies [MESH]
  • |Glomerular Filtration Rate [MESH]
  • |Hematuria/complications/*pathology [MESH]
  • |Humans [MESH]
  • |Logistic Models [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Proportional Hazards Models [MESH]
  • |Proteins/analysis [MESH]
  • |Renal Insufficiency, Chronic/complications/mortality/*pathology [MESH]
  • |Risk Factors [MESH]
  • |Severity of Illness Index [MESH]


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