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2015 ; 5
(ä): 15242
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Microscopic Haematuria and Clinical Outcomes in Patients With Stage 3-5
Nondiabetic Chronic Kidney Disease
#MMPMID26472621
You-Hsien Lin H
; Yen CY
; Lim LM
; Hwang DY
; Tsai JC
; Hwang SJ
; Hung CC
; Chen HC
Sci Rep
2015[Oct]; 5
(ä): 15242
PMID26472621
show ga
Microscopic haematuria is proposed as a prognostic factor for renal outcomes in
patients with glomerulonephritis. However, the role of haematuria in patients
with advanced chronic kidney disease (CKD) or heavy proteinuria has not been
investigated. We divided 1799 patients with stage 3-5 nondiabetic CKD into 3
groups according to the results from 3 urinalyses: no haematuria (0-2 red blood
cells [RBCs]/hpf ?2 times), mild haematuria (2-5 RBCs/hpf ?2 times) and moderate
haematuria (?5-10?RBCs/hpf ?2 times). The estimated glomerular filtration rate
was 25.4?mL/min/1.73?m(2), with a urine protein-to-creatinine ratio (UPCR) of
881?mg/g. The hazard ratios (HRs) of mild and moderate haematuria for end-stage
renal disease (ESRD) were 1.28 (95% confidence interval [CI]: 1.05-1.56,
P?=?0.024) and 1.34 (95% CI: 1.03-1.74, P?=?0.030), respectively. The HR of
moderate haematuria for mortality was 1.56 (95% CI: 1.11-2.20, P?=?0.011).
According to subgroup analysis, the HR of moderate haematuria for ESRD in
patients with a UPCR of <500?mg/g was more prominent than that in patients with a
UPCR of ?500?mg/g. Microscopic haematuria in patients with stage 3-5 nondiabetic
CKD is associated with increased risks of ESRD and mortality.