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10.1002/path.4581 http://scihub22266oqcxt.onion/10.1002/path.4581 C4607608!4607608!26119426     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pathol 2015 ; 237 (3): 355-62 Nephropedia Template TP {{tp|p=26119426|t=2015. Many Private Mutations Originate From The First Few Divisions Of A Human Colorectal Adenoma |pdf=|usr=}}{{26119426}} gab.com Text Many Private Mutations Originate From The First Few Divisions Of A Human Colorectal Adenoma JO: J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26119426 #FOAvip Intratumoral mutational heterogeneity (ITH) or the presence of different private mutations in different parts of the same tumor is commonly observed in human tumors. The mechanisms generating such ITH are uncertain. Here we find ITH can be remarkably well-structured by measuring point mutations, chromosome copy numbers and DNA passenger methylation from opposite sides and individual glands of a 6 cm human colorectal adenoma. ITH was present between tumor sides and individual glands, but the private mutations were side specific and subdivided the adenoma into two major subclones. Furthermore, ITH disappeared within individual glands because the glands were clonal populations composed of cells with identical mutant genotypes. Despite mutation clonality, the glands were relatively old, diverse populations when their individual cells were compared for passenger methylation and by FISH. These observations can be organized into an expanding star-like ancestral tree with co-clonal expansion, where many private mutations and multiple related clones arise during the first few divisions. As a consequence, most detectable mutational ITH in the final tumor originates from the first few divisions. Much of the early history of a tumor, especially the first few divisions, may be embedded within the detectable ITH of tumor genomes. Twit Text FOAVip Many Private Mutations Originate From The First Few Divisions Of A Human Colorectal Adenoma ????J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26119426 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26119426 #FOAvip English Wikipedia <ref>{{Cite pmid|26119426}}</ref> Many Private Mutations Originate From The First Few Divisions Of A Human Colorectal Adenoma #MMPMID26119426 Kang H; Salomon MP; Sottoriva A; Zhao J; Toy M; Press MF; Curtis C; Marjoram P; Siegmund K; Shibata D J Pathol 2015[Nov]; 237 (3): 355-62 PMID26119426show ga Intratumoral mutational heterogeneity (ITH) or the presence of different private mutations in different parts of the same tumor is commonly observed in human tumors. The mechanisms generating such ITH are uncertain. Here we find ITH can be remarkably well-structured by measuring point mutations, chromosome copy numbers and DNA passenger methylation from opposite sides and individual glands of a 6 cm human colorectal adenoma. ITH was present between tumor sides and individual glands, but the private mutations were side specific and subdivided the adenoma into two major subclones. Furthermore, ITH disappeared within individual glands because the glands were clonal populations composed of cells with identical mutant genotypes. Despite mutation clonality, the glands were relatively old, diverse populations when their individual cells were compared for passenger methylation and by FISH. These observations can be organized into an expanding star-like ancestral tree with co-clonal expansion, where many private mutations and multiple related clones arise during the first few divisions. As a consequence, most detectable mutational ITH in the final tumor originates from the first few divisions. Much of the early history of a tumor, especially the first few divisions, may be embedded within the detectable ITH of tumor genomes. äMany Private Mutations Originate From The First Few Divisions Of A Hum(epmc).pdf DeepDyve Pubget Overpricing