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10.1002/path.4574 http://scihub22266oqcxt.onion/10.1002/path.4574 C4607582!4607582!26095930     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pathol 2015 ; 237 (3): 285-95 Nephropedia Template TP {{tp|p=26095930|t=2015. CD47 deficiency ameliorates autoimmune nephritis in Faslpr mice by suppressing IgG autoantibody production |pdf=|usr=}}{{26095930}} gab.com Text CD47 deficiency ameliorates autoimmune nephritis in Faslpr mice by suppressing IgG autoantibody production JO: J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26095930 #FOAvip CD47, a self-recognition marker, plays an important role in both innate and adaptive immune response. To explore the potential role of CD47 in activation of autoreactive T and B cells and the production of autoantibodies in autoimmune disease, especially systemic lupus erythematosus (SLE), we have generated CD47 knockout Faslpr (CD47?/??Faslpr) mice and examined histopathologic changes in the kidneys, cumulative survival rates, proteinuria, extent of splenomegaly and autoantibodies, serum chemistry and immunologic parameters. In comparison with Faslpr mice, CD47?/??Faslpr mice exhibit a prolonged lifespan and delayed autoimmune nephritis including glomerular cell proliferation, basement membrane thickening, acute tubular atrophy and vacuolization. CD47?/??Faslpr mice have lower levels of proteinuria, associated with reduced deposition of complement C3 and C1q, and IgG but not IgM in the glomeruli, compared to the age-matched Faslpr mice. Serum levels of antinuclear antibodies and anti-double-stranded DNA antibodies are significantly lower in CD47?/??Faslpr mice than in Faslpr mice. CD47?/??Faslpr mice also display less pronounced splenomegaly than Faslpr mice. The mechanistic studies further suggest that CD47 deficiency impairs the antigenic challenge-induced production of IgG but not IgM, and that this effect is associated with reduction of T follicular cells and impairment of germinal center development in lymphoid tissues. In conclusion, our results demonstrate that CD47 deficiency ameliorates lupus nephritis in Faslpr mice via suppression of IgG autoantibody production. Twit Text FOAVip CD47 deficiency ameliorates autoimmune nephritis in Faslpr mice by suppressing IgG autoantibody production ????J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26095930 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26095930 #FOAvip English Wikipedia <ref>{{Cite pmid|26095930}}</ref> CD47 deficiency ameliorates autoimmune nephritis in Faslpr mice by suppressing IgG autoantibody production #MMPMID26095930 Shi L; Bian Z; Chen CXJ; Guo YN; Lv Z; Zeng C; Liu Z; Zen K; Liu Y J Pathol 2015[Nov]; 237 (3): 285-95 PMID26095930show ga CD47, a self-recognition marker, plays an important role in both innate and adaptive immune response. To explore the potential role of CD47 in activation of autoreactive T and B cells and the production of autoantibodies in autoimmune disease, especially systemic lupus erythematosus (SLE), we have generated CD47 knockout Faslpr (CD47?/??Faslpr) mice and examined histopathologic changes in the kidneys, cumulative survival rates, proteinuria, extent of splenomegaly and autoantibodies, serum chemistry and immunologic parameters. In comparison with Faslpr mice, CD47?/??Faslpr mice exhibit a prolonged lifespan and delayed autoimmune nephritis including glomerular cell proliferation, basement membrane thickening, acute tubular atrophy and vacuolization. CD47?/??Faslpr mice have lower levels of proteinuria, associated with reduced deposition of complement C3 and C1q, and IgG but not IgM in the glomeruli, compared to the age-matched Faslpr mice. Serum levels of antinuclear antibodies and anti-double-stranded DNA antibodies are significantly lower in CD47?/??Faslpr mice than in Faslpr mice. CD47?/??Faslpr mice also display less pronounced splenomegaly than Faslpr mice. The mechanistic studies further suggest that CD47 deficiency impairs the antigenic challenge-induced production of IgG but not IgM, and that this effect is associated with reduction of T follicular cells and impairment of germinal center development in lymphoid tissues. In conclusion, our results demonstrate that CD47 deficiency ameliorates lupus nephritis in Faslpr mice via suppression of IgG autoantibody production. äCD47 deficiency ameliorates autoimmune nephritis in Faslpr mice by sup(epmc).pdf DeepDyve Pubget Overpricing