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10.1093/gbe/evv166 http://scihub22266oqcxt.onion/10.1093/gbe/evv166 C4607523!4607523!26319403     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Biol+Evol 2015 ; 7 (9): 2569-84 Nephropedia Template TP {{tp|p=26319403|t=2015. Natural Selection at the Brush-Border: Adaptations to Carbohydrate Diets in Humans and Other Mammals |pdf=|usr=}}{{26319403}} gab.com Text Natural Selection at the Brush-Border: Adaptations to Carbohydrate Diets in Humans and Other Mammals JO: Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=26319403 #FOAvip Dietary shifts can drive molecular evolution in mammals and a major transition in human history, the agricultural revolution, favored carbohydrate consumption. We investigated the evolutionary history of nine genes encoding brush-border proteins involved in carbohydrate digestion/absorption. Results indicated widespread adaptive evolution in mammals, with several branches experiencing episodic selection, particularly strong in bats. Many positively selected sites map to functional protein regions (e.g., within glucosidase catalytic crevices), with parallel evolution at SI (sucrase-isomaltase) and MGAM (maltase-glucoamylase). In human populations, five genes were targeted by positive selection acting on noncoding variants within regulatory elements. Analysis of ancient DNA samples indicated that most derived alleles were already present in the Paleolithic. Positively selected variants at SLC2A5 (fructose transporter) were an exception and possibly spread following the domestication of specific fruit crops. We conclude that agriculture determined no major selective event at carbohydrate metabolism genes in humans, with implications for susceptibility to metabolic disorders. Twit Text FOAVip Natural Selection at the Brush-Border: Adaptations to Carbohydrate Diets in Humans and Other Mammals ????Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=26319403 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26319403 #FOAvip English Wikipedia <ref>{{Cite pmid|26319403}}</ref> Natural Selection at the Brush-Border: Adaptations to Carbohydrate Diets in Humans and Other Mammals #MMPMID26319403 Pontremoli C; Mozzi A; Forni D; Cagliani R; Pozzoli U; Menozzi G; Vertemara J; Bresolin N; Clerici M; Sironi M Genome Biol Evol 2015[Sep]; 7 (9): 2569-84 PMID26319403show ga Dietary shifts can drive molecular evolution in mammals and a major transition in human history, the agricultural revolution, favored carbohydrate consumption. We investigated the evolutionary history of nine genes encoding brush-border proteins involved in carbohydrate digestion/absorption. Results indicated widespread adaptive evolution in mammals, with several branches experiencing episodic selection, particularly strong in bats. Many positively selected sites map to functional protein regions (e.g., within glucosidase catalytic crevices), with parallel evolution at SI (sucrase-isomaltase) and MGAM (maltase-glucoamylase). In human populations, five genes were targeted by positive selection acting on noncoding variants within regulatory elements. Analysis of ancient DNA samples indicated that most derived alleles were already present in the Paleolithic. Positively selected variants at SLC2A5 (fructose transporter) were an exception and possibly spread following the domestication of specific fruit crops. We conclude that agriculture determined no major selective event at carbohydrate metabolism genes in humans, with implications for susceptibility to metabolic disorders. äNatural Selection at the Brush-Border: Adaptations to Carbohydrate Die(epmc).pdf DeepDyve Pubget Overpricing