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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Foodborne+Pathog+Dis
2014 ; 11
(6
): 447-55
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gab.com Text
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English Wikipedia
Global incidence of human Shiga toxin-producing Escherichia coli infections and
deaths: a systematic review and knowledge synthesis
#MMPMID24750096
Majowicz SE
; Scallan E
; Jones-Bitton A
; Sargeant JM
; Stapleton J
; Angulo FJ
; Yeung DH
; Kirk MD
Foodborne Pathog Dis
2014[Jun]; 11
(6
): 447-55
PMID24750096
show ga
OBJECTIVES: Shiga toxin-producing Escherichia coli (STEC) are an important cause
of foodborne disease, yet global estimates of disease burden do not exist. Our
objective was to estimate the global annual number of illnesses due to pathogenic
STEC, and resultant hemolytic uremic syndrome (HUS), end-stage renal disease
(ESRD), and death. MATERIALS: We searched Medline, Scopus, SIGLE/OpenGrey, and
CABI and World Health Organization (WHO) databases for studies of STEC incidence
in the general population, published between January 1, 1990 and April 30, 2012,
in all languages. We searched health institution websites for notifiable disease
data and reports, cross-referenced citations, and consulted international
knowledge experts. We employed an a priori hierarchical study selection process
and synthesized results using a stochastic simulation model to account for
uncertainty inherent in the data. RESULTS: We identified 16 articles and
databases from 21 countries, from 10 of the 14 WHO Sub-Regions. We estimated that
STEC causes 2,801,000 acute illnesses annually (95% Credible Interval [Cr.I.]:
1,710,000; 5,227,000), and leads to 3890 cases of HUS (95% Cr.I.: 2400; 6700),
270 cases of ESRD (95% Cr.I.: 20; 800), and 230 deaths (95% Cr.I.: 130; 420).
Sensitivity analyses indicated these estimates are likely conservative.
CONCLUSIONS: These are the first estimates of the global incidence of
STEC-related illnesses, which have not been explicitly included in previous
global burden of disease estimations. Compared to other pathogens with a
foodborne transmission component, STEC appears to cause more cases than alveolar
echinococcosis each year, but less than typhoid fever, foodborne trematodes, and
nontyphoidal salmonellosis. APPLICATIONS: Given the persistence of STEC globally,
efforts aimed at reducing the burden of foodborne disease should consider the
relative contribution of STEC in the target population.
|*Global Health
[MESH]
|*Models, Biological
[MESH]
|Escherichia coli Infections/*epidemiology/microbiology/mortality/prevention &
control
[MESH]
|Foodborne Diseases/*epidemiology/microbiology/mortality/prevention & control
[MESH]