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2015 ; 43
(3
): 515-26
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Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal
Dendritic Cells and Drive Protective Cutaneous Immunity
#MMPMID26377898
Kashem SW
; Riedl MS
; Yao C
; Honda CN
; Vulchanova L
; Kaplan DH
Immunity
2015[Sep]; 43
(3
): 515-26
PMID26377898
show ga
Innate resistance to Candida albicans in mucosal tissues requires the production
of interleukin-17A (IL-17A) by tissue-resident cells early during infection, but
the mechanism of cytokine production has not been precisely defined. In the skin,
we found that dermal ?? T cells were the dominant source of IL-17A during
C. albicans infection and were required for pathogen resistance. Induction of
IL-17A from dermal ?? T cells and resistance to C. albicans required IL-23
production from CD301b(+) dermal dendritic cells (dDCs). In addition, we found
that sensory neurons were directly activated by C. albicans. Ablation of sensory
neurons increased susceptibility to C. albicans infection, which could be rescued
by exogenous addition of the neuropeptide CGRP. These data define a model in
which nociceptive pathways in the skin drive production of IL-23 by CD301b(+)
dDCs resulting in IL-17A production from ?? T cells and resistance to cutaneous
candidiasis.