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10.1155/2015/152741 http://scihub22266oqcxt.onion/10.1155/2015/152741 C4606169!4606169 !26495321     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26495321 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol+Res 2015 ; 2015 (ä): 152741 Nephropedia Template TP {{tp|p=26495321 |t=2015. Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis |pdf=|usr=}}{{26495321 }} gab.com Text Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26495321 #FOAvip Interleukin-10 overproduction has been associated with worse prognosis in human cutaneous leishmaniasis, while IFN-?-dependent responses are associated with parasite killing and host protection. Innovative strategies are needed to overcome therapeutic failure observed in endemic areas. The use of monoclonal antibody-based immunotherapy targeting IL-10 cytokine was evaluated here. Partial IL-10 blockade in Leishmania braziliensis whole soluble antigen-stimulated cells from endemic area CL patients with active or healed lesions and asymptomatic controls was evaluated. Overall decrease in IL-10, IL-4, and TNF-? production was observed in all groups of subjects. Only patients with active lesions still produced some levels of TNF-? after anti-IL-10 stimulation in association with Leishmania antigens. Moreover, this strategy showed limited modulatory effects on IFN-?-dependent chemokine CXCL10 production. Results suggest the potential immunotherapeutic use of partial IL-10 blockade in localized cutaneous leishmaniasis. Twit Text FOAVip Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26495321 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26495321 #FOAvip English Wikipedia <ref>{{Cite pmid|26495321 }}</ref> Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis #MMPMID26495321 Castellano LR ; Argiro L ; Dessein H ; Dessein A ; da Silva MV ; Correia D ; Rodrigues V J Immunol Res 2015[]; 2015 (ä): 152741 PMID26495321 show ga Interleukin-10 overproduction has been associated with worse prognosis in human cutaneous leishmaniasis, while IFN-?-dependent responses are associated with parasite killing and host protection. Innovative strategies are needed to overcome therapeutic failure observed in endemic areas. The use of monoclonal antibody-based immunotherapy targeting IL-10 cytokine was evaluated here. Partial IL-10 blockade in Leishmania braziliensis whole soluble antigen-stimulated cells from endemic area CL patients with active or healed lesions and asymptomatic controls was evaluated. Overall decrease in IL-10, IL-4, and TNF-? production was observed in all groups of subjects. Only patients with active lesions still produced some levels of TNF-? after anti-IL-10 stimulation in association with Leishmania antigens. Moreover, this strategy showed limited modulatory effects on IFN-?-dependent chemokine CXCL10 production. Results suggest the potential immunotherapeutic use of partial IL-10 blockade in localized cutaneous leishmaniasis. |Adult [MESH] |Antibodies, Monoclonal/pharmacology/*therapeutic use [MESH] |Chemokines/metabolism [MESH] |Cytokines/metabolism [MESH] |Humans [MESH] |Immunomodulation/drug effects [MESH] |Interleukin-10/*antagonists & inhibitors/*metabolism [MESH] |Leishmaniasis, Cutaneous/*drug therapy/immunology/*metabolism [MESH] |Leukocytes, Mononuclear/immunology/metabolism [MESH] |Male [MESH]Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in (epmc).pdf DeepDyve Pubget Overpricing