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10.1155/2015/578453 http://scihub22266oqcxt.onion/10.1155/2015/578453 C4606082!4606082!26495302     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26495302|t=2015. The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury |pdf=|usr=}}{{26495302}} gab.com Text The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26495302 #FOAvip A rise in osmotic concentration (osmolarity) activates the transcription factor Nuclear Factor of Activated T Cells 5 (NFAT5, also known as Tonicity-responsive Enhancer Binding Protein, TonEBP). This is part of a regulatory mechanism of cells adjusting to environments of high osmolarity. Under physiological conditions these are particularly important in the kidney. Activation of NFAT5 results in the modulation of various genes including some which promote inflammation. The osmolarity increases in patients with renal failure. Additionally, in peritoneal dialysis the cells of the peritoneal cavity are repeatedly exposed to a rise and fall in osmotic concentrations. Here we review the current information about NFAT5 activation in uremic patients and patients on peritoneal dialysis. We suggest that high osmolarity promotes injury in the ?uremic? milieu, which results in inflammation locally in the peritoneal membrane, but most likely also in the systemic circulation. Twit Text FOAVip The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26495302 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26495302 #FOAvip English Wikipedia <ref>{{Cite pmid|26495302}}</ref> The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury #MMPMID26495302 Seeger H; Kitterer D; Latus J; Alscher MD; Braun N; Segerer S Biomed Res Int 2015[]; 2015 (ä): ä PMID26495302show ga A rise in osmotic concentration (osmolarity) activates the transcription factor Nuclear Factor of Activated T Cells 5 (NFAT5, also known as Tonicity-responsive Enhancer Binding Protein, TonEBP). This is part of a regulatory mechanism of cells adjusting to environments of high osmolarity. Under physiological conditions these are particularly important in the kidney. Activation of NFAT5 results in the modulation of various genes including some which promote inflammation. The osmolarity increases in patients with renal failure. Additionally, in peritoneal dialysis the cells of the peritoneal cavity are repeatedly exposed to a rise and fall in osmotic concentrations. Here we review the current information about NFAT5 activation in uremic patients and patients on peritoneal dialysis. We suggest that high osmolarity promotes injury in the ?uremic? milieu, which results in inflammation locally in the peritoneal membrane, but most likely also in the systemic circulation. äThe Potential Role of NFAT5 and Osmolarity in Peritoneal Injury (epmc).pdf DeepDyve Pubget Overpricing