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2015 ; 29
(9
): 715-24
Nephropedia Template TP
gab.com Text
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English Wikipedia
Maternal Anti-Fetal Brain IgG Autoantibodies and Autism Spectrum Disorder:
Current Knowledge and its Implications for Potential Therapeutics
#MMPMID26369920
Fox-Edmiston E
; Van de Water J
CNS Drugs
2015[Sep]; 29
(9
): 715-24
PMID26369920
show ga
Several studies have found a correlation between the presence of circulating
maternal autoantibodies and neuronal dysfunction in the neonate. Specifically,
maternal anti-brain autoantibodies, which may access the fetal compartment during
gestation, have been identified as one risk factor for developing autism spectrum
disorder (ASD). Studies by our laboratory elucidated seven neurodevelopmental
proteins recognized by maternal autoantibodies whose presence is associated with
a diagnosis of maternal autoantibody-related (MAR) autism in the child. While the
specific process of anti-brain autoantibody generation is unclear and the
detailed pathogenic mechanisms are currently unknown, identification of the
maternal autoantibody targets increases the therapeutic possibilities. The
potential therapies discussed in this review provide a framework for possible
future medical interventions.