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10.3233/ACP-CLO-2010-0536 http://scihub22266oqcxt.onion/10.3233/ACP-CLO-2010-0536 C4605813!4605813!20978326     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Anal+Cell+Pathol+(Amst) 2010 ; 33 (5-6): 207-16 Nephropedia Template TP {{tp|p=20978326|t=2010. Role of Pituitary Tumour Transforming Gene 1 in Medullary Thyroid Carcinoma |pdf=|usr=}}{{20978326}} gab.com Text Role of Pituitary Tumour Transforming Gene 1 in Medullary Thyroid Carcinoma JO: Anal Cell Pathol (Amst) http://www.kidney.de/pget.php?&tw=1&pmid=20978326 #FOAvip Background: Pituitary tumour transforming gene 1 (PTTG1) is over-expressed in a variety of endocrine-related tumours. We aimed at evaluating PTTG1 expression and function in human neoplastic parafollicular C-cells, represented by medullary thyroid carcinoma (MTC) and C-cell hyperplasia (CCH) samples and by the TT cell line.Methods: TT cells and tissues derived from human CCH (8 samples) and MTC (12 samples) were analyzed by northern blot, furthermore TT cells were subjected to PTTG gene silencing and cells were analyzed for DNA synthesis.Results: PTTG1 expression was significantly higher (p < 0.01) in CCH (3-fold), in papillary thyroid cancer and in MTC (5-fold) than in normal thyroid, and in MTC lymph-node metastases as compared to primary lesions (~2-fold; p < 0.05). PTTG1 mRNA and protein correlated with tumour diameter and TNM status (p < 0.05). In TT cells, PTTG1 silencing did not completely block DNA synthesis, but significantly reduced [3H]Thymidine incorporation (~50%; p < 0.01) for up to 3 days.Conclusion: PTTG1 levels correlate with tumour aggressiveness. PTTG1 silencing causes reduced MTC cell proliferation, supporting the hypothesis that PTTG1 might have an important role in C-cell neoplastic proliferation. Twit Text FOAVip Role of Pituitary Tumour Transforming Gene 1 in Medullary Thyroid Carcinoma ????Anal Cell Pathol (Amst) http://www.kidney.de/pget.php?&tw=1&pmid=20978326 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20978326 #FOAvip English Wikipedia <ref>{{Cite pmid|20978326}}</ref> Role of Pituitary Tumour Transforming Gene 1 in Medullary Thyroid Carcinoma #MMPMID20978326 Zatelli MC; Tagliati F; Amodio V; Buratto M; Pelizzo M; Pansini G; Bondanelli M; Ambrosio MR; Uberti ECd Anal Cell Pathol (Amst) 2010[]; 33 (5-6): 207-16 PMID20978326show ga Background: Pituitary tumour transforming gene 1 (PTTG1) is over-expressed in a variety of endocrine-related tumours. We aimed at evaluating PTTG1 expression and function in human neoplastic parafollicular C-cells, represented by medullary thyroid carcinoma (MTC) and C-cell hyperplasia (CCH) samples and by the TT cell line.Methods: TT cells and tissues derived from human CCH (8 samples) and MTC (12 samples) were analyzed by northern blot, furthermore TT cells were subjected to PTTG gene silencing and cells were analyzed for DNA synthesis.Results: PTTG1 expression was significantly higher (p < 0.01) in CCH (3-fold), in papillary thyroid cancer and in MTC (5-fold) than in normal thyroid, and in MTC lymph-node metastases as compared to primary lesions (~2-fold; p < 0.05). PTTG1 mRNA and protein correlated with tumour diameter and TNM status (p < 0.05). In TT cells, PTTG1 silencing did not completely block DNA synthesis, but significantly reduced [3H]Thymidine incorporation (~50%; p < 0.01) for up to 3 days.Conclusion: PTTG1 levels correlate with tumour aggressiveness. PTTG1 silencing causes reduced MTC cell proliferation, supporting the hypothesis that PTTG1 might have an important role in C-cell neoplastic proliferation. äRole of Pituitary Tumour Transforming Gene 1 in Medullary Thyroid Carc(epmc).pdf DeepDyve Pubget Overpricing