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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Anal+Cell+Pathol+(Amst) 2012 ; 35 (2): 117-22 Nephropedia Template TP
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Histopathologic Patterns of Nervous System Tumors Based on Computer Vision Methods and Whole Slide Imaging (WSI) #MMPMID22063730
Walkowski S; Szymas J
Anal Cell Pathol (Amst) 2012[]; 35 (2): 117-22 PMID22063730show ga
Background: Making an automatic diagnosis based on virtual slides and whole slide imaging or even determining whether a case belongs to a single class, representing a specific disease, is a big challenge. In this work we focus on WHO Classification of Tumours of the Central Nervous System. We try to design a method which allows to automatically distinguish virtual slides which contain histopathologic patterns characteristic of glioblastoma ? pseudopalisading necrosis and discriminate cases with neurinoma (schwannoma), which contain similar structures ? palisading (Verocay bodies).Methods: Our method is based on computer vision approaches like structural analysis and shape descriptors. We start with image segmentation in a virtual slide, find specific patterns and use a set of features which can describe pseudopalisading necrosis and distinguish it from palisades. Type of structures found in a slide decides about its classification.Results: Described method is tested on a set of 49 virtual slides, captured using robotic microscope. Results show that 82% of glioblastoma cases and 90% of neurinoma cases were correctly identified by the proposed algorithm.Conclusion: Our method is a promising approach to automatic detection of nervous system tumors using virtual slides.