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10.1111/hpb.12472

http://scihub22266oqcxt.onion/10.1111/hpb.12472
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C4605343!4605343!26292846
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suck abstract from ncbi


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pmid26292846      HPB+(Oxford) 2015 ; 17 (11): 1033-9
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  • Systematic review on the use of matrix-bound sealants in pancreatic resection #MMPMID26292846
  • Smits FJ; van Santvoort HC; Besselink MGH; Borel Rinkes IHM; Molenaar IQ
  • HPB (Oxford) 2015[Nov]; 17 (11): 1033-9 PMID26292846show ga
  • Background: Pancreatic fistula is a potentially life-threatening complication after a pancreatic resection. The aim of this systematic review was to evaluate the role of matrix-bound sealants after a pancreatic resection in terms of preventing or ameliorating the course of a post-operative pancreatic fistula. Methods: A systematic search was performed in the literature from May 2005 to April 2015. Included were clinical studies using matrix-bound sealants after a pancreatic resection, reporting a post-operative pancreatic fistula (POPF) according to the International Study Group on Pancreatic Fistula classification, in which grade B and C fistulae were considered clinically relevant. Results: Two were studies on patients undergoing pancreatoduodenectomy (sealants n = 67, controls n = 27) and four studies on a distal pancreatectomy (sealants n = 258, controls n = 178). After a pancreatoduodenectomy, 13% of patients treated with sealants versus 11% of patients without sealants developed a POPF (P = 0.76), of which 4% versus 4% were clinically relevant (P = 0.87). After a distal pancreatectomy, 42% of patients treated with sealants versus 52% of patients without sealants developed a POPF (P = 0.03). Of these, 9% versus 12% were clinically relevant (P = 0.19). Conclusions: The present data do not support the routine use of matrix-bound sealants after a pancreatic resection, as there was no effect on clinically relevant POPF. Larger, well-designed studies are needed to determine the efficacy of sealants in preventing POPF after a pancreatoduodenectomy.
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