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10.3109/14767058.2014.980808

http://scihub22266oqcxt.onion/10.3109/14767058.2014.980808
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C4605271!4605271!25354285
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suck abstract from ncbi


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pmid25354285      J+Matern+Fetal+Neonatal+Med 2015 ; 28 (18): 2135-40
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  • Is preeclampsia associated with fetal malformation? A review and report of original research #MMPMID25354285
  • Nelson DB; Chalak LF; McIntire DD; Leveno KJ
  • J Matern Fetal Neonatal Med 2015[Dec]; 28 (18): 2135-40 PMID25354285show ga
  • Objective: To examine fetal malformations in mother?infant pairs with and without pregnancy-related hypertension. Methods: This was an observational, population-based study of women delivering a singleton at our hospital. Specific fetal malformations identified in women with gestational hypertension or preeclampsia were compared to those without pregnancy-related hypertension. Women with chronic hypertension, superimposed preeclampsia on chronic hypertension and pregestational diabetes were excluded. Results: Between March 2002 and December 2012, a total of 151 997 women delivered, and 10 492 (7%) had preeclampsia, 4282 (3%) had gestational hypertension and 137 223 (90%) were referent normotensive controls. Women with preeclampsia were significantly more likely to deliver infants with malformations when compared to normotensive controls (2.5% versus 1.6%, p < 0.001), whereas women with gestational hypertension were not (1.9% versus 1.6%, p = 0.16). The overall risk for fetal malformation associated with preeclampsia remained significant following logistic regression for age, race, parity and maternal body-habitus (adjusted OR 1.5; 95% CI: 1.3?1.7). Only single-organ system malformations ? microcephaly and hypospadias ? remained associated with preeclampsia (p < 0.001), and fetal growth restriction was a co-factor for both. Conclusions: Preeclampsia was associated with increased rates of fetal malformations when compared to normotensive women ? specifically microcephaly and hypospadias. These associations appear predominantly as a consequence of impaired fetal growth.
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