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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biomed+Res+Int 2015 ; 2015 (ä): ä Nephropedia Template TP
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T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1 #MMPMID26491691
Trad M; Gautheron A; Fraszczak J; Alizadeh D; Larmonier C; LaCasse CJ; Centuori S; Audia S; Samson M; Ciudad M; Bonnefoy F; Lemaire-Ewing S; Katsanis E; Perruche S; Saas P; Bonnotte B
Biomed Res Int 2015[]; 2015 (ä): ä PMID26491691show ga
T lymphocytes activated by dendritic cells (DC) which present tumor antigens play a key role in the antitumor immune response. However, in patients suffering from active cancer, DC are not efficient at initiating and supporting immune responses as they participate to T lymphocyte inhibition. DC in the tumor environment are functionally defective and exhibit a characteristic of immature phenotype, different to that of DC present in nonpathological conditions. The mechanistic bases underlying DC dysfunction in cancer responsible for the modulation of T-cell responses and tumor immune escape are still being investigated. Using two different mouse tumor models, we showed that tumor-infiltrating DC (TIDC) are constitutively immunosuppressive, exhibit a semimature phenotype, and impair responder T lymphocyte proliferation and activation by a mechanism involving CD39 ectoenzyme.