Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/jth.12897 http://scihub22266oqcxt.onion/10.1111/jth.12897 C4604745!4604745!26149025     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Thromb+Haemost 2015 ; 13 (0 1): S200-7 Nephropedia Template TP {{tp|p=26149025|t=2015. New insights into the biology of tissue factor pathway inhibitor |pdf=|usr=}}{{26149025}} gab.com Text New insights into the biology of tissue factor pathway inhibitor JO: J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=26149025 #FOAvip Tissue factor pathway inhibitor (TFPI) dampens the initiation of blood coagulation by inhibiting two potent procoagulant complexes, tissue factor?factor VIIa (TF?FVIIa) and early forms of prothrombinase. TFPI isoforms, TFPI? and TFPI?, result from alternative splicing of mRNA, producing distinct C-terminal ends of the two proteins. Both isoforms inhibit TF?FVIIa, but only TFPI? can inhibit early forms of prothrombinase by binding of its positively charged C-terminus with high affinity to the acidic B-domain exosite of FVa, which is generated upon activation by FXa. TFPI? and TFPI? are produced in cultured human endothelial cells, while platelets contain only TFPI?. Knowledge of the anticoagulant mechanisms and tissue expression patterns of TFPI? and TFPI? have improved our understanding of the phenotypes observed in different mouse models of TFPI deficiency, the east Texas bleeding disorder, and the development of pharmaceutical agents that block TFPI function to treat hemophilia. Twit Text FOAVip New insights into the biology of tissue factor pathway inhibitor ????J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=26149025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26149025 #FOAvip English Wikipedia <ref>{{Cite pmid|26149025}}</ref> New insights into the biology of tissue factor pathway inhibitor #MMPMID26149025 MARONEY SA; MAST AE J Thromb Haemost 2015[Jun]; 13 (0 1): S200-7 PMID26149025show ga Tissue factor pathway inhibitor (TFPI) dampens the initiation of blood coagulation by inhibiting two potent procoagulant complexes, tissue factor?factor VIIa (TF?FVIIa) and early forms of prothrombinase. TFPI isoforms, TFPI? and TFPI?, result from alternative splicing of mRNA, producing distinct C-terminal ends of the two proteins. Both isoforms inhibit TF?FVIIa, but only TFPI? can inhibit early forms of prothrombinase by binding of its positively charged C-terminus with high affinity to the acidic B-domain exosite of FVa, which is generated upon activation by FXa. TFPI? and TFPI? are produced in cultured human endothelial cells, while platelets contain only TFPI?. Knowledge of the anticoagulant mechanisms and tissue expression patterns of TFPI? and TFPI? have improved our understanding of the phenotypes observed in different mouse models of TFPI deficiency, the east Texas bleeding disorder, and the development of pharmaceutical agents that block TFPI function to treat hemophilia. äNew insights into the biology of tissue factor pathway inhibitor (epmc).pdf DeepDyve Pubget Overpricing