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10.1186/s12876-015-0359-2 http://scihub22266oqcxt.onion/10.1186/s12876-015-0359-2 C4604710!4604710!26463759     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Gastroenterol 2015 ; 15 (ä): ä Nephropedia Template TP {{tp|p=26463759|t=2015. Investigation of potential early Histologic markers of pediatric inflammatory bowel disease |pdf=|usr=}}{{26463759}} gab.com Text Investigation of potential early Histologic markers of pediatric inflammatory bowel disease JO: BMC Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=26463759 #FOAvip Background: Early manifestations of pediatric inflammatory bowel disease (IBD) can be relatively nonspecific. Initial mucosal biopsies may not be conclusive, delaying the diagnosis until subsequent biopsies demonstrate typical histologic features of IBD. We hypothesized that certain inflammatory cell types may be utilized as early histologic indicators of IBD in children. Methods: A retrospective analysis compared histologic findings from initially inconclusive or negative endoscopic studies in 22 patients who were subsequently diagnosed with IBD (after diagnostic endoscopy) to those of 20 comparison patients with functional abdominal pain matched for age, gender, and study type. A pediatric pathologist, blinded to study group, reviewed biopsies for histologic abnormalities. Eosinophil densities were obtained from the stomach, duodenum, and rectosigmoid areas. Immunohistochemistry (IHC) staining for tumor necrosis factor-? (TNF-?) and matrix metalloproteinase-9 (MMP-9) was performed on the stomach and rectosigmoid areas. Results: Gastritis and colonic crypt distortion were present in the IBD group at a greater rate (61 % vs. 22 %, p?=?0.020; 34 % vs. 4 %, p?=?0.008, respectively). Peak and mean eosinophil densities in the rectosigmoid area were greater in the IBD group (17.0/hpf vs. 5.0/hpf, p?=?0.0063; 12.3/hpf vs. 4.2/hpf, p?=?0.0106, respectively). TNF-? and MMP-9 staining did not reveal any significant differences. Conclusions: Our data suggests that significantly greater inflammation in the stomach, crypt distortion in the colon, and eosinophilia in the rectosigmoid distinguished the IBD group from the comparison group at the time of the initial endoscopic evaluation. Twit Text FOAVip Investigation of potential early Histologic markers of pediatric inflammatory bowel disease ????BMC Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=26463759 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26463759 #FOAvip English Wikipedia <ref>{{Cite pmid|26463759}}</ref> Investigation of potential early Histologic markers of pediatric inflammatory bowel disease #MMPMID26463759 Bass JA; Friesen CA; Deacy AD; Neilan NA; Bracken JM; Shakhnovich V; Singh V BMC Gastroenterol 2015[]; 15 (ä): ä PMID26463759show ga Background: Early manifestations of pediatric inflammatory bowel disease (IBD) can be relatively nonspecific. Initial mucosal biopsies may not be conclusive, delaying the diagnosis until subsequent biopsies demonstrate typical histologic features of IBD. We hypothesized that certain inflammatory cell types may be utilized as early histologic indicators of IBD in children. Methods: A retrospective analysis compared histologic findings from initially inconclusive or negative endoscopic studies in 22 patients who were subsequently diagnosed with IBD (after diagnostic endoscopy) to those of 20 comparison patients with functional abdominal pain matched for age, gender, and study type. A pediatric pathologist, blinded to study group, reviewed biopsies for histologic abnormalities. Eosinophil densities were obtained from the stomach, duodenum, and rectosigmoid areas. Immunohistochemistry (IHC) staining for tumor necrosis factor-? (TNF-?) and matrix metalloproteinase-9 (MMP-9) was performed on the stomach and rectosigmoid areas. Results: Gastritis and colonic crypt distortion were present in the IBD group at a greater rate (61 % vs. 22 %, p?=?0.020; 34 % vs. 4 %, p?=?0.008, respectively). Peak and mean eosinophil densities in the rectosigmoid area were greater in the IBD group (17.0/hpf vs. 5.0/hpf, p?=?0.0063; 12.3/hpf vs. 4.2/hpf, p?=?0.0106, respectively). TNF-? and MMP-9 staining did not reveal any significant differences. Conclusions: Our data suggests that significantly greater inflammation in the stomach, crypt distortion in the colon, and eosinophilia in the rectosigmoid distinguished the IBD group from the comparison group at the time of the initial endoscopic evaluation. äInvestigation of potential early Histologic markers of pediatric infla(epmc).pdf DeepDyve Pubget Overpricing