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10.1038/srep15024 http://scihub22266oqcxt.onion/10.1038/srep15024 C4604494!4604494!26463008     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26463008|t=2015. How astrocyte networks may contribute to cerebral metabolite clearance |pdf=|usr=}}{{26463008}} gab.com Text How astrocyte networks may contribute to cerebral metabolite clearance JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26463008 #FOAvip The brain possesses an intricate network of interconnected fluid pathways that are vital to the maintenance of its homeostasis. With diffusion being the main mode of solute transport in cerebral tissue, it is not clear how bulk flow through these pathways is involved in the removal of metabolites. In this computational study, we show that networks of astrocytes may contribute to the passage of solutes between tissue and paravascular spaces (PVS) by serving as low resistance pathways to bulk water flow. The astrocyte networks are connected through aquaporin-4 (AQP4) water channels with a parallel, extracellular route carrying metabolites. Inhibition of the intracellular route by deletion of AQP4 causes a reduction of bulk flow between tissue and PVS, leading to reduced metabolite clearance into the venous PVS or, as observed in animal studies, a reduction of tracer influx from arterial PVS into the brain tissue. Twit Text FOAVip How astrocyte networks may contribute to cerebral metabolite clearance ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26463008 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26463008 #FOAvip English Wikipedia <ref>{{Cite pmid|26463008}}</ref> How astrocyte networks may contribute to cerebral metabolite clearance #MMPMID26463008 Asgari M; de Zélicourt D; Kurtcuoglu V Sci Rep 2015[]; 5 (ä): ä PMID26463008show ga The brain possesses an intricate network of interconnected fluid pathways that are vital to the maintenance of its homeostasis. With diffusion being the main mode of solute transport in cerebral tissue, it is not clear how bulk flow through these pathways is involved in the removal of metabolites. In this computational study, we show that networks of astrocytes may contribute to the passage of solutes between tissue and paravascular spaces (PVS) by serving as low resistance pathways to bulk water flow. The astrocyte networks are connected through aquaporin-4 (AQP4) water channels with a parallel, extracellular route carrying metabolites. Inhibition of the intracellular route by deletion of AQP4 causes a reduction of bulk flow between tissue and PVS, leading to reduced metabolite clearance into the venous PVS or, as observed in animal studies, a reduction of tracer influx from arterial PVS into the brain tissue. äHow astrocyte networks may contribute to cerebral metabolite clearance(epmc).pdf DeepDyve Pubget Overpricing