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10.1038/srep15066 http://scihub22266oqcxt.onion/10.1038/srep15066 C4604466!4604466!26463758     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26463758|t=2015. Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation |pdf=|usr=}}{{26463758}} gab.com Text Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26463758 #FOAvip Polyreactive antibodies are a major component of the natural antibody repertoire and bind to a variety of structurally unrelated molecules. These antibodies are thought to provide a first line of defense against bacterial infections and play a major role in the clearance of apoptotic cells. What triggers the secretion of these antibodies has remained an enigma. Using a surrogate assay for measuring polyreactive antibodies, we found that about 50% of serum IgM is polyreactive and that stimulation of TLR4+/+, but not TLR4?/?, mice resulted in a 40 fold increase in polyreactive antibodies. Stimulation of TLRs 3, 7, 9 also increased the secretion of polyreactive antibodies. Infection with a virus or tissue damage induced by a toxin similarly led to an increase in polyreactive antibodies in MyD88+/+, but not MyD88?/? mice. We conclude that stimulation of TLRs is a key link in the mechanism of polyreactive antibody secretion into the circulation. Twit Text FOAVip Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26463758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26463758 #FOAvip English Wikipedia <ref>{{Cite pmid|26463758}}</ref> Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation #MMPMID26463758 Gunti S; Messer RJ; Xu C; Yan M; Coleman WG; Peterson KE; Hasenkrug KJ; Notkins AL Sci Rep 2015[]; 5 (ä): ä PMID26463758show ga Polyreactive antibodies are a major component of the natural antibody repertoire and bind to a variety of structurally unrelated molecules. These antibodies are thought to provide a first line of defense against bacterial infections and play a major role in the clearance of apoptotic cells. What triggers the secretion of these antibodies has remained an enigma. Using a surrogate assay for measuring polyreactive antibodies, we found that about 50% of serum IgM is polyreactive and that stimulation of TLR4+/+, but not TLR4?/?, mice resulted in a 40 fold increase in polyreactive antibodies. Stimulation of TLRs 3, 7, 9 also increased the secretion of polyreactive antibodies. Infection with a virus or tissue damage induced by a toxin similarly led to an increase in polyreactive antibodies in MyD88+/+, but not MyD88?/? mice. We conclude that stimulation of TLRs is a key link in the mechanism of polyreactive antibody secretion into the circulation. äStimulation of Toll-Like Receptors profoundly influences the titer of (epmc).pdf DeepDyve Pubget Overpricing