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10.1038/srep15066 http://scihub22266oqcxt.onion/10.1038/srep15066 C4604466!4604466 !26463758     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26463758 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 15066 Nephropedia Template TP {{tp|p=26463758 |t=2015. Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation |pdf=|usr=}}{{26463758 }} gab.com Text Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26463758 #FOAvip Polyreactive antibodies are a major component of the natural antibody repertoire and bind to a variety of structurally unrelated molecules. These antibodies are thought to provide a first line of defense against bacterial infections and play a major role in the clearance of apoptotic cells. What triggers the secretion of these antibodies has remained an enigma. Using a surrogate assay for measuring polyreactive antibodies, we found that about 50% of serum IgM is polyreactive and that stimulation of TLR4(+/+), but not TLR4(-/-), mice resulted in a 40 fold increase in polyreactive antibodies. Stimulation of TLRs 3, 7, 9 also increased the secretion of polyreactive antibodies. Infection with a virus or tissue damage induced by a toxin similarly led to an increase in polyreactive antibodies in MyD88(+/+), but not MyD88(-/-) mice. We conclude that stimulation of TLRs is a key link in the mechanism of polyreactive antibody secretion into the circulation. Twit Text FOAVip Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26463758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26463758 #FOAvip English Wikipedia <ref>{{Cite pmid|26463758 }}</ref> Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation #MMPMID26463758 Gunti S ; Messer RJ ; Xu C ; Yan M ; Coleman WG Jr ; Peterson KE ; Hasenkrug KJ ; Notkins AL Sci Rep 2015[Oct]; 5 (ä): 15066 PMID26463758 show ga Polyreactive antibodies are a major component of the natural antibody repertoire and bind to a variety of structurally unrelated molecules. These antibodies are thought to provide a first line of defense against bacterial infections and play a major role in the clearance of apoptotic cells. What triggers the secretion of these antibodies has remained an enigma. Using a surrogate assay for measuring polyreactive antibodies, we found that about 50% of serum IgM is polyreactive and that stimulation of TLR4(+/+), but not TLR4(-/-), mice resulted in a 40 fold increase in polyreactive antibodies. Stimulation of TLRs 3, 7, 9 also increased the secretion of polyreactive antibodies. Infection with a virus or tissue damage induced by a toxin similarly led to an increase in polyreactive antibodies in MyD88(+/+), but not MyD88(-/-) mice. We conclude that stimulation of TLRs is a key link in the mechanism of polyreactive antibody secretion into the circulation. |Animals [MESH] |Autoantibodies/*blood/*immunology [MESH] |Female [MESH] |Immunity, Innate/*immunology [MESH] |Immunization/*methods [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Toll-Like Receptors/*immunology [MESH]Stimulation of Toll-Like Receptors profoundly influences the titer of (epmc).pdf DeepDyve Pubget Overpricing