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10.1039/c5an00780a

http://scihub22266oqcxt.onion/10.1039/c5an00780a
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C4604043!4604043!26171467
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suck abstract from ncbi


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pmid26171467      Analyst 2015 ; 140 (21): 7062-81
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  • Biomarker detection for disease diagnosis using cost-effective microfluidic platforms #MMPMID26171467
  • Sanjay ST; Fu G; Dou M; Xu F; Liu R; Qi H; Li X
  • Analyst 2015[Nov]; 140 (21): 7062-81 PMID26171467show ga
  • Early and timely detection of disease biomarkers can prevent the spread of infectious diseases, and drastically decrease the death rate of people suffering from different diseases such as cancer and infectious diseases. Because conventional diagnostic methods have limited application in low-resource settings due to the use of bulky and expensive instrumentation, simple and low-cost point-of-care diagnostic devices for timely and early biomarker diagnosis, is the need of the hour, especially in rural areas and developing nations. The microfluidics technology possesses remarkable features for simple, low-cost, and rapid disease diagnosis. There have been significant advances in the development of microfluidic platforms for diseases biomarker detection. This article reviews recent advances in biomarker detection using cost-effective microfluidic devices for disease diagnosis, with the emphasis on infectious disease and cancer diagnosis in low-resource settings. This review first introduces different microfluidic platforms (e.g. polymer and paper-based microfluidics) used for disease diagnosis, with a brief description of their common fabrication techniques. Then, it highlights various detection strategies for disease biomarker detection using microfluidic platforms, including colorimetric, fluorescence, chemiluminescence, electrochemiluminescence (ECL), and electrochemical detection. Finally, it discusses the current limitations of microfluidics devices for disease biomarker detection and the future perspectives.
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