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10.1002/eji.200939782 http://scihub22266oqcxt.onion/10.1002/eji.200939782 C4603937!4603937 !20101618     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20101618 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Immunol 2010 ; 40 (4 ): 1022-35 Nephropedia Template TP {{tp|p=20101618 |t=2010. Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg |pdf=|usr=}}{{20101618 }} gab.com Text Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=20101618 #FOAvip DC apoptosis has been observed in patients with cancer and sepsis, and defects in DC apoptosis have been implicated in the development of autoimmune diseases. However, the mechanisms of how DC apoptosis affects immune responses, are unclear. In this study, we showed that immature viable DC have the ability to uptake apoptotic DC as well as necrotic DC without it being recognized as an inflammatory event by immature viable DC. However, the specific uptake of apoptotic DC converted immature viable DC into tolerogenic DC, which were resistant to LPS-induced maturation. These tolerogenic DC secreted increased levels of TGF-beta1, which induced differentiation of naïve T cells into Foxp3(+) Treg. Furthermore, induction of Treg differentiation only occurred upon uptake of apoptotic DC and not apoptotic splenocytes by viable DC, indicating that it is specifically the uptake of apoptotic DC that gives viable immature DC the potential to induce Foxp3(+) Treg. Taken together, these findings identify uptake of apoptotic DC by viable immature DC as an immunologically tolerogenic event. Twit Text FOAVip Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=20101618 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20101618 #FOAvip English Wikipedia <ref>{{Cite pmid|20101618 }}</ref> Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg #MMPMID20101618 Kushwah R ; Wu J ; Oliver JR ; Jiang G ; Zhang J ; Siminovitch KA ; Hu J Eur J Immunol 2010[Apr]; 40 (4 ): 1022-35 PMID20101618 show ga DC apoptosis has been observed in patients with cancer and sepsis, and defects in DC apoptosis have been implicated in the development of autoimmune diseases. However, the mechanisms of how DC apoptosis affects immune responses, are unclear. In this study, we showed that immature viable DC have the ability to uptake apoptotic DC as well as necrotic DC without it being recognized as an inflammatory event by immature viable DC. However, the specific uptake of apoptotic DC converted immature viable DC into tolerogenic DC, which were resistant to LPS-induced maturation. These tolerogenic DC secreted increased levels of TGF-beta1, which induced differentiation of naïve T cells into Foxp3(+) Treg. Furthermore, induction of Treg differentiation only occurred upon uptake of apoptotic DC and not apoptotic splenocytes by viable DC, indicating that it is specifically the uptake of apoptotic DC that gives viable immature DC the potential to induce Foxp3(+) Treg. Taken together, these findings identify uptake of apoptotic DC by viable immature DC as an immunologically tolerogenic event. |*Apoptosis/drug effects/radiation effects [MESH] |Animals [MESH] |B7-2 Antigen/biosynthesis/genetics [MESH] |CD4-Positive T-Lymphocytes/cytology/immunology [MESH] |Coculture Techniques [MESH] |Dendritic Cells/cytology/drug effects/*immunology/metabolism/radiation effects [MESH] |Forkhead Transcription Factors/*analysis [MESH] |Immune Tolerance/*immunology [MESH] |Interleukin-12/biosynthesis/genetics [MESH] |Intracellular Signaling Peptides and Proteins/physiology [MESH] |Lipopolysaccharides/pharmacology [MESH] |Lymphopoiesis [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Necrosis [MESH] |Phagocytosis/*immunology [MESH] |Protein Biosynthesis [MESH] |Protein Serine-Threonine Kinases/physiology [MESH] |Spleen/cytology/immunology [MESH] |T-Lymphocytes, Regulatory/cytology/*immunology [MESH] |TOR Serine-Threonine Kinases [MESH]Uptake of apoptotic DC converts immature DC into tolerogenic DC that i(epmc).pdf DeepDyve Pubget Overpricing