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10.1111/micc.12064 http://scihub22266oqcxt.onion/10.1111/micc.12064 C4603760!4603760 !23647512     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23647512 &cmd=llinks): Failed to open stream: HTTP request failed! 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Improvement in middle cerebral artery structure and endothelial function in stroke-prone spontaneously hypertensive rats after macrophage depletion |pdf=|usr=}}{{23647512 }} gab.com Text Improvement in middle cerebral artery structure and endothelial function in stroke-prone spontaneously hypertensive rats after macrophage depletion JO: Microcirculation http://www.kidney.de/pget.php?&tw=1&pmid=23647512 #FOAvip BACKGROUND: Inflammation is involved in the pathogenesis of hypertension. Hypertensive animals have an increased number of perivascular macrophages in cerebral arteries. Macrophages might be involved in remodeling of the cerebral vasculature. We hypothesized that peripheral macrophage depletion would improve MCA structure and function in hypertensive rats. METHODS: For macrophage depletion, six-week-old stroke-prone spontaneously hypertensive rats (SHRSP) were treated with CLOD, 10 mL/kg every three or four days, i.p., or vehicle (PBS lipo). MCA structure and function were analyzed by pressure and wire myography. RESULTS: Blood pressure was not affected by CLOD. The number of perivascular CD163-positive cells per microscopic field was reduced in the brain of SHRSP+CLOD. CLOD treatment caused an improvement in endothelium-dependent dilation after intralumenal perfusion of ADP and incubation with Ach. Inhibition of NO production blunted the Ach response, and endothelium-independent dilation was not altered. At an intralumenal pressure of 80 mmHg, MCA from SHRSP+CLOD showed increased lumen diameter, decreased wall thickness, and wall-to-lumen ratio. Cross-sectional area of pial arterioles from SHRSP+CLOD was higher than PBS lipo. CONCLUSIONS: These results suggest that macrophage depletion attenuates MCA remodeling and improves MCA endothelial function in SHRSP. Twit Text FOAVip Improvement in middle cerebral artery structure and endothelial function in stroke-prone spontaneously hypertensive rats after macrophage depletion ????Microcirculation http://www.kidney.de/pget.php?&tw=1&pmid=23647512 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23647512 #FOAvip English Wikipedia <ref>{{Cite pmid|23647512 }}</ref> Improvement in middle cerebral artery structure and endothelial function in stroke-prone spontaneously hypertensive rats after macrophage depletion #MMPMID23647512 Pires PW ; Girgla SS ; McClain JL ; Kaminski NE ; van Rooijen N ; Dorrance AM Microcirculation 2013[Oct]; 20 (7 ): 650-61 PMID23647512 show ga BACKGROUND: Inflammation is involved in the pathogenesis of hypertension. Hypertensive animals have an increased number of perivascular macrophages in cerebral arteries. Macrophages might be involved in remodeling of the cerebral vasculature. We hypothesized that peripheral macrophage depletion would improve MCA structure and function in hypertensive rats. METHODS: For macrophage depletion, six-week-old stroke-prone spontaneously hypertensive rats (SHRSP) were treated with CLOD, 10 mL/kg every three or four days, i.p., or vehicle (PBS lipo). MCA structure and function were analyzed by pressure and wire myography. RESULTS: Blood pressure was not affected by CLOD. The number of perivascular CD163-positive cells per microscopic field was reduced in the brain of SHRSP+CLOD. CLOD treatment caused an improvement in endothelium-dependent dilation after intralumenal perfusion of ADP and incubation with Ach. Inhibition of NO production blunted the Ach response, and endothelium-independent dilation was not altered. At an intralumenal pressure of 80 mmHg, MCA from SHRSP+CLOD showed increased lumen diameter, decreased wall thickness, and wall-to-lumen ratio. Cross-sectional area of pial arterioles from SHRSP+CLOD was higher than PBS lipo. CONCLUSIONS: These results suggest that macrophage depletion attenuates MCA remodeling and improves MCA endothelial function in SHRSP. |*Blood Pressure [MESH] |*Cerebrovascular Circulation [MESH] |*Macrophages [MESH] |*Vasodilation [MESH] |Animals [MESH] |Bone Density Conservation Agents/pharmacology [MESH] |Clodronic Acid/pharmacology [MESH] |Endothelium, Vascular/*physiopathology [MESH] |Male [MESH] |Middle Cerebral Artery/*physiopathology [MESH] |Rats [MESH]Improvement in middle cerebral artery structure and endothelial functi(epmc).pdf DeepDyve Pubget Overpricing