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10.2147/COPD.S92062 http://scihub22266oqcxt.onion/10.2147/COPD.S92062 C4603716!4603716 !26504377     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26504377 &cmd=llinks): Failed to open stream: HTTP request failed! 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Wheezing, a significant clinical phenotype of COPD: experience from the Taiwan Obstructive Lung Disease Study |pdf=|usr=}}{{26504377 }} gab.com Text Wheezing, a significant clinical phenotype of COPD: experience from the Taiwan Obstructive Lung Disease Study JO: Int J Chron Obstruct Pulmon Dis http://www.kidney.de/pget.php?&tw=1&pmid=26504377 #FOAvip BACKGROUND: COPD is an important public health challenge with significant heterogeneity of clinical presentation and disease progression. Clinicians have been trying to find phenotypes that may be linked to distinct prognoses and different therapeutic choices. Not all patients with COPD present with wheezing, a possible clinical phenotype that can help differentiate patient subgroups. METHODS: The Taiwan Obstructive Lung Disease study was a retrospective, multicenter research study to investigate the treatment patterns of COPD after the implementation of the Global Initiative for Chronic Obstructive Lung Disease 2011 guidelines. Between November 2012 and August 2013, medical records were retrieved from patients with COPD aged ?40 years; patients diagnosed with asthma were excluded. Demographic data, lung function, symptom scores, and acute exacerbation were recorded and analyzed, and the differences between patients with and without wheezing were evaluated. RESULTS: Of the 1,096 patients with COPD, 424 (38.7%) had the wheezing phenotype. The wheezing group had significantly higher COPD Assessment Test scores (12.4±7.8 versus 10.5±6.7, P<0.001), higher modified Medical Research Council grade (2.0±1.0 versus 1.7±0.9, P<0.001), and more acute exacerbations within the past year (0.9±1.3 versus 0.4±0.9, P<0.001) than the nonwheezing group. The postbronchodilator forced expiratory volume in 1 second was lower in wheezing patients (1.2±0.5 L versus 1.5±0.6 L, P<0.001). Even in patients with maintenance treatment fitting the Global Initiative for Chronic Obstructive Lung Disease 2011 guidelines, the wheezing group still had worse symptom scores and more exacerbations. CONCLUSION: Wheezing is an important phenotype in patients with COPD. Patients with COPD having the wheezing phenotype are associated with worse symptoms, more exacerbations, and worse lung function. Twit Text FOAVip Wheezing, a significant clinical phenotype of COPD: experience from the Taiwan Obstructive Lung Disease Study ????Int J Chron Obstruct Pulmon Dis http://www.kidney.de/pget.php?&tw=1&pmid=26504377 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26504377 #FOAvip English Wikipedia <ref>{{Cite pmid|26504377 }}</ref> Wheezing, a significant clinical phenotype of COPD: experience from the Taiwan Obstructive Lung Disease Study #MMPMID26504377 Huang WC ; Tsai YH ; Wei YF ; Kuo PH ; Tao CW ; Cheng SL ; Lee CH ; Wu YK ; Chen NH ; Hsu WH ; Hsu JY ; Wang CC ; Lin MS Int J Chron Obstruct Pulmon Dis 2015[]; 10 (ä): 2121-6 PMID26504377 show ga BACKGROUND: COPD is an important public health challenge with significant heterogeneity of clinical presentation and disease progression. Clinicians have been trying to find phenotypes that may be linked to distinct prognoses and different therapeutic choices. Not all patients with COPD present with wheezing, a possible clinical phenotype that can help differentiate patient subgroups. METHODS: The Taiwan Obstructive Lung Disease study was a retrospective, multicenter research study to investigate the treatment patterns of COPD after the implementation of the Global Initiative for Chronic Obstructive Lung Disease 2011 guidelines. Between November 2012 and August 2013, medical records were retrieved from patients with COPD aged ?40 years; patients diagnosed with asthma were excluded. Demographic data, lung function, symptom scores, and acute exacerbation were recorded and analyzed, and the differences between patients with and without wheezing were evaluated. RESULTS: Of the 1,096 patients with COPD, 424 (38.7%) had the wheezing phenotype. The wheezing group had significantly higher COPD Assessment Test scores (12.4±7.8 versus 10.5±6.7, P<0.001), higher modified Medical Research Council grade (2.0±1.0 versus 1.7±0.9, P<0.001), and more acute exacerbations within the past year (0.9±1.3 versus 0.4±0.9, P<0.001) than the nonwheezing group. The postbronchodilator forced expiratory volume in 1 second was lower in wheezing patients (1.2±0.5 L versus 1.5±0.6 L, P<0.001). Even in patients with maintenance treatment fitting the Global Initiative for Chronic Obstructive Lung Disease 2011 guidelines, the wheezing group still had worse symptom scores and more exacerbations. CONCLUSION: Wheezing is an important phenotype in patients with COPD. Patients with COPD having the wheezing phenotype are associated with worse symptoms, more exacerbations, and worse lung function. |*Pulmonary Disease, Chronic Obstructive/diagnosis/epidemiology/physiopathology [MESH] |*Respiratory Sounds/diagnosis/etiology/physiopathology [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Disease Progression [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Phenotype [MESH] |Physical Examination/methods [MESH] |Respiratory Function Tests/methods [MESH] |Retrospective Studies [MESH] |Severity of Illness Index [MESH] |Symptom Flare Up [MESH]Wheezing, a significant clinical phenotype of COPD: experience from th(epmc).pdf DeepDyve Pubget Overpricing