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10.1021/jacs.5b06586 http://scihub22266oqcxt.onion/10.1021/jacs.5b06586 C4603548!4603548!26280087     free     free     free       J+Am+Chem+Soc 2015 ; 137 (34): 10922-5 Nephropedia Template TP {{tp|p=26280087|t=2015. Extended O-GlcNAc on HLA class-I-bound peptides |pdf=|usr=}}{{26280087}} gab.com Text Extended O-GlcNAc on HLA class-I-bound peptides JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=26280087 #FOAvip We report unexpected mass spectrometric observations of glycosylated human leukocyte antigen (HLA) class I-bound peptides. Complemented by molecular modeling, in vitro enzymatic assays, and oxonium ion patterns, we propose that the observed O-linked glycans carrying up to five monosaccharides are extended O-GlcNAc?s rather than GalNAc-initiated O-glycans. A cytosolic O-GlcNAc modification is normally terminal and does not extend to produce a polysaccharide, but O-GlcNAc on an HLA peptide presents a special case because the loaded HLA class I complex traffics through the endoplasmic reticulum and Golgi apparatus on its way to the cell membrane, and is hence exposed to glycosyltransferases. In addition we report for the first time natural HLA class I presentation of O- and N-linked glycopeptides derived from membrane proteins. HLA class I peptides with centrally located oligosaccharides have been shown to be immunogenic and may therefore be important targets for immune-surveillance. Twit Text FOAVip Extended O-GlcNAc on HLA class-I-bound peptides ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=26280087 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26280087 #FOAvip English Wikipedia <ref>{{Cite pmid|26280087}}</ref> Extended O-GlcNAc on HLA class-I-bound peptides #MMPMID26280087 Marino F; Bern M; Mommen GP; Leney AC; van Gaans-van den Brink JA; Bonvin AM; Becker C; van Els CA; Heck AJR J Am Chem Soc 2015[Sep]; 137 (34): 10922-5 PMID26280087show ga We report unexpected mass spectrometric observations of glycosylated human leukocyte antigen (HLA) class I-bound peptides. Complemented by molecular modeling, in vitro enzymatic assays, and oxonium ion patterns, we propose that the observed O-linked glycans carrying up to five monosaccharides are extended O-GlcNAc?s rather than GalNAc-initiated O-glycans. A cytosolic O-GlcNAc modification is normally terminal and does not extend to produce a polysaccharide, but O-GlcNAc on an HLA peptide presents a special case because the loaded HLA class I complex traffics through the endoplasmic reticulum and Golgi apparatus on its way to the cell membrane, and is hence exposed to glycosyltransferases. In addition we report for the first time natural HLA class I presentation of O- and N-linked glycopeptides derived from membrane proteins. HLA class I peptides with centrally located oligosaccharides have been shown to be immunogenic and may therefore be important targets for immune-surveillance. äExtended O-GlcNAc on HLA class-I-bound peptides (epmc).pdf DeepDyve Pubget Overpricing