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10.1002/acn3.229

http://scihub22266oqcxt.onion/10.1002/acn3.229
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C4603380!4603380!26478897
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suck abstract from ncbi


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pmid26478897      Ann+Clin+Transl+Neurol 2015 ; 2 (10): 972-7
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  • Fine mapping of chromosome 15q25 implicates ZNF592 in neurosarcoidosis patients #MMPMID26478897
  • Lareau CA; Adrianto I; Levin AM; Iannuzzi MC; Rybicki BA; Montgomery CG
  • Ann Clin Transl Neurol 2015[Oct]; 2 (10): 972-7 PMID26478897show ga
  • Neurosarcoidosis is a clinical subtype of sarcoidosis characterized by the presence of granulomas in the nervous system. Here, we report a highly significant association with a variant (rs75652600, P = 3.12 × 10?8, odds ratios = 4.34) within a zinc finger gene, ZNF592, from an imputation-based fine-mapping study of the chromosomal region 15q25 in African-Americans with neurosarcoidosis. We validate the association with ZNF592, a gene previously shown to cause cerebellar ataxia, in a cohort of European-Americans with neurosarcoidosis by uncovering low-frequency variants with a similar risk effect size (chr15:85309284, P = 0.0021, odds ratios = 5.36).
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