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10.1186/s40246-015-0048-9 http://scihub22266oqcxt.onion/10.1186/s40246-015-0048-9 C4603341!4603341 !26463173     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26463173 &cmd=llinks): Failed to open stream: HTTP request failed! 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Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotype |pdf=|usr=}}{{26463173 }} gab.com Text Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotype JO: Hum Genomics http://www.kidney.de/pget.php?&tw=1&pmid=26463173 #FOAvip BACKGROUND: The CpG island methylator phenotype (CIMP) was first characterized in colorectal cancer but since has been extensively studied in several other tumor types such as breast, bladder, lung, and gastric. CIMP is of clinical importance as it has been reported to be associated with prognosis or response to treatment. However, the identification of a universal molecular basis to define CIMP across tumors has remained elusive. RESULTS: We perform a genome-wide methylation analysis of over 2000 tumor samples from 5 cancer sites to assess the existence of a CIMP with common molecular basis across cancers. We then show that the CIMP phenotype is associated with specific gene expression variations. However, we do not find a common genetic signature in all tissues associated with CIMP. CONCLUSION: Our results suggest the existence of a universal epigenetic and transcriptomic signature that defines the CIMP across several tumor types but does not indicate the existence of a common genetic signature of CIMP. Twit Text FOAVip Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotype ????Hum Genomics http://www.kidney.de/pget.php?&tw=1&pmid=26463173 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26463173 #FOAvip English Wikipedia <ref>{{Cite pmid|26463173 }}</ref> Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotype #MMPMID26463173 Moarii M ; Reyal F ; Vert JP Hum Genomics 2015[Oct]; 9 (ä): 26 PMID26463173 show ga BACKGROUND: The CpG island methylator phenotype (CIMP) was first characterized in colorectal cancer but since has been extensively studied in several other tumor types such as breast, bladder, lung, and gastric. CIMP is of clinical importance as it has been reported to be associated with prognosis or response to treatment. However, the identification of a universal molecular basis to define CIMP across tumors has remained elusive. RESULTS: We perform a genome-wide methylation analysis of over 2000 tumor samples from 5 cancer sites to assess the existence of a CIMP with common molecular basis across cancers. We then show that the CIMP phenotype is associated with specific gene expression variations. However, we do not find a common genetic signature in all tissues associated with CIMP. CONCLUSION: Our results suggest the existence of a universal epigenetic and transcriptomic signature that defines the CIMP across several tumor types but does not indicate the existence of a common genetic signature of CIMP. |*Gene Expression Regulation, Neoplastic [MESH] |Biomarkers, Tumor [MESH] |CpG Islands/genetics [MESH] |DNA Methylation/*genetics [MESH] |Databases, Genetic [MESH] |Genome, Human [MESH] |Humans [MESH] |Mutation [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Proteins/*biosynthesis/genetics [MESH] |Neoplasms/*genetics/pathology [MESH]Integrative DNA methylation and gene expression analysis to assess the(epmc).pdf DeepDyve Pubget Overpricing