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2015 ; 2015
(ä): 796120
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Comparison of Fine Needle Aspiration and Fine Needle Nonaspiration Cytology of
Thyroid Nodules: A Meta-Analysis
#MMPMID26491689
Song H
; Wei C
; Li D
; Hua K
; Song J
; Maskey N
; Fang L
Biomed Res Int
2015[]; 2015
(ä): 796120
PMID26491689
show ga
BACKGROUND: Fine needle aspiration cytology (FNAC) and fine needle nonaspiration
cytology (FNNAC) are useful cost-effective techniques for preoperatively
assessing thyroid lesions. Both techniques have advantages and disadvantages, and
there is controversy over which method is superior. This meta-analysis was
performed to evaluate the differences between FNAC and FNNAC for diagnosis of
thyroid nodules. METHODS: Primary publications were independently collected by
two reviewers from PubMed, Web of Science, Google Scholar, EBSCO, OALib, and the
Cochrane Library databases. The following search terms were used: fine needle,
aspiration, capillary, nonaspiration, sampling without aspiration, thyroid, and
cytology. The last search was performed on February 1, 2015. RESULTS: Sixteen
studies comprising 1,842 patients and 2,221 samples were included in this study.
No statistically significant difference was observed between FNAC and FNNAC
groups with respect to diagnostically inadequate smears, diagnostically superior
smears, diagnostic performance (accuracy, sensitivity, specificity, negative
predictive value, and positive predictive value), area under the summary receiver
operating characteristic curve, average score of each parameter (background blood
or clot, amount of cellular material, degree of cellular degeneration, degree of
cellular trauma, and retention of appropriate architecture), and total score of
five parameters. CONCLUSION: FNAC and FNNAC are equally useful in assessing
thyroid nodules.