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2015 ; 94
(17
): e685
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English Wikipedia
Probiotics for standard triple Helicobacter pylori eradication: a randomized,
double-blind, placebo-controlled trial
#MMPMID25929897
Hauser G
; Salkic N
; Vukelic K
; JajacKnez A
; Stimac D
Medicine (Baltimore)
2015[May]; 94
(17
): e685
PMID25929897
show ga
The primary objective in the study is determination of efficacy of probiotic
preparation as a supportive therapy in eradication of Helicobacter pylori.The
study was multicenter, prospective, randomized, placebo controlled, and
double-blind. The subjects first filled out a specially designed questionnaire to
assess the severity of the 10 symptoms, which can be related to eradication
therapy to be monitored during the trial. Each subject then received 28 capsules
of probiotic preparation or matching placebo capsules, which they were supposed
to take over the following 14 days, twice a day, at least 2?hours prior to or
after the antibiotic therapy administration.A total of 804 patients were enrolled
in the trial, of which 650 (80.85%) were included in the analysis. The results
show a significantly larger share of cured subjects in the probiotic arm versus
the placebo arm (87.38% vs 72.55%; P?0.001). Additionally, presence and
intensity of epigastric pain, bloating, flatulence, taste disturbance, loss of
appetite, nausea, vomiting, heartburn, rash, and diarrhea were monitored over the
study period. At 15 days postinclusion, probiotic treatment was found superior to
placebo in 7 of 10 mentioned symptoms. Average intensity for symptoms potentially
related to antibiotic therapy was significantly higher in the placebo group, 0.76
vs 0.55 (P?0.001).Adding probiotics to the standard triple therapy for H pylori
eradication significantly contributes to treatment efficacy and distinctly
decreases the adverse effects of therapy and the symptoms of the underlying
disease.
|*Bifidobacterium
[MESH]
|*Helicobacter pylori
[MESH]
|*Lacticaseibacillus rhamnosus
[MESH]
|2-Pyridinylmethylsulfinylbenzimidazoles/therapeutic use
[MESH]