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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(29
): e1188
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Minor-but-Complex Liver Resection: An Alternative to Major Resections for
Colorectal Liver Metastases Involving the Hepato-Caval Confluence
#MMPMID26200628
Urbani L
; Masi G
; Puccini M
; Colombatto P
; Vivaldi C
; Balestri R
; Marioni A
; Prosperi V
; Forfori F
; Licitra G
; Leoni C
; Paolicchi A
; Boraschi P
; Lunardi A
; Tascini C
; Castagna M
; Buccianti P
Medicine (Baltimore)
2015[Jul]; 94
(29
): e1188
PMID26200628
show ga
Major hepatectomy (MH) is often considered the only possible approach for
colorectal liver metastasis (CRLM) at the hepato-caval confluence (CC), but it is
associated with high morbidity and mortality. With the aim to reduce MH, we
developed the "minor-but-complex" (MbC) technique, which consists in the
resection of less than 3 adjacent liver segments with exposure of the CC and
preservation of hepatic outflow until spontaneous maturation of peripheral
intrahepatic shunts between main hepatic veins. We have evaluated applicability
and outcome of MbC resections for the treatment of CRLM involving the CC. In this
retrospective cohort study, all consecutive liver resections (LR) performed for
CRLM located in segments 1, 7, 8, or 4a were classified as MINOR - removal of <3
adjacent segments; MbC - removal of <3 adjacent segments with CC exposure; and MH
- removal of ? 3 adjacent segments. The rate of avoided MH was obtained by the
difference between the rate of potentially MH (PMH) plus potentially inoperable
cases and the rate of the MH performed. Taking into account that postoperative
mortality is mainly related to the amount of resected liver, MbC was compared
with minor resections for safety, complexity, and outcome. Of the 59 LR analyzed,
29 (49.1%) were deemed PMH and 4 (6.8%) potentially inoperable. Eventually, MH
was performed only in 8 (13.5%) with a decrease rate of 42.4%. Minor LR was
performed in 23 (39.0%) and MbC LR in 28 (47.5%) patients. Among MbC cases, 32.1%
had previous liver treatments, 39.3% required vascular reconstruction (no
reconstructed vessel thrombosis occurred before maturation of peripheral
intrahepatic shunts between main hepatic veins), and 7.1% had grade IIIb-IV
complications, their median hospital stay was 9 days and 90-day mortality was 0%.
After a median follow-up of 22.2 months, oncological results were comparable with
those of minor resections. MbC hepatectomy lowers the need for MH and allows for
the resection of potentially inoperable patients without negative impact on
safety and survival.