Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25634172
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25634172
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(4
): e419
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Clinical analysis of 61 systemic lupus erythematosus patients with intestinal
pseudo-obstruction and/or ureterohydronephrosis: a retrospective observational
study
#MMPMID25634172
Xu N
; Zhao J
; Liu J
; Wu D
; Zhao L
; Wang Q
; Hou Y
; Li M
; Zhang W
; Zeng X
; Fang W
; Huang X
; Zhang X
; Tian X
; Zhao Y
; Zeng X
; Zhang F
Medicine (Baltimore)
2015[Jan]; 94
(4
): e419
PMID25634172
show ga
The objective of this article is to investigate the clinical features of
intestinal pseudo-obstruction (IPO) and/or ureterohydronephrosis in systemic
lupus erythematosus (SLE). Sixty-one SLE patients with IPO and/or
ureterohydronephrosis were analyzed retrospectively. A total of 183 cases were
randomly selected as controls from 3840 SLE inpatients without IPO and
ureterohydronephrosis during the same period. Patients were assigned to 1 of the
3 groups (SLE with IPO and ureterohydronephrosis, SLE with IPO, and SLE with
ureterohydronephrosis). The clinical characteristics, treatments, and prognosis
were compared between the 3 groups. There were 57 females and 4 males, with a
mean age of 32.0 years. IPO was the initial manifestation of SLE in 49.1% of the
cases, whereas ureterohydronephrosis in 32.5%. All patients were initially
treated with a high-dose steroid. Thirty-one of these patients (50.8%) also
received intravenous methylprednisolone pulse therapy. Two patients died of bowel
perforation and lupus encephalopathy, and the other 59 patients (96.7%) achieved
remission after treatment. The incidences of fever, glomerulonephritis, nervous
system involvement, serositis, erythrocyte sedimentation rate elevation,
hypoalbuminemia, hypocomplementemia, and anti-SSA antibody positivity were
significantly higher in patients with IPO and/or ureterohydronephrosis than in
the control group (without IPO and ureterohydronephrosis). Also, patients with
IPO and/or ureterohydronephrosis had higher SLE Disease Activity Index scores
than control patients. Compared with SLE patients with IPO, the patients with IPO
and ureterohydronephrosis had a significantly higher incidence of gallbladder
wall thickening, biliary tract dilatation, and serositis, whereas the patients
with ureterohydronephrosis had less mucocutaneous involvement and serositis.
Eight of the 47 IPO patients who initially responded well to immunotherapy
relapsed; however, all responded well to retreatment with adequate immunotherapy.
Of these 8 patients, 4 relapsed following poor compliance and
self-discontinuation of steroid or immunosuppressant therapy. The rate of poor
compliance with immunotherapy and the number of organ systems involved in
patients in the recurrent IPO group were significantly higher than those in the
nonrecurrent IPO group. IPO and ureterohydronephrosis are severe complications of
SLE. As patients usually respond readily to early optimal steroid treatment,
early diagnosis and timely initiation of glucocorticoid are important to relieve
symptoms, prevent complications, and improve prognosis.