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2015 ; 94
(4
): e496
Nephropedia Template TP
gab.com Text
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English Wikipedia
Associations of antiphospholipid antibodies with splanchnic vein thrombosis: a
systematic review with meta-analysis
#MMPMID25634200
Qi X
; De Stefano V
; Su C
; Bai M
; Guo X
; Fan D
Medicine (Baltimore)
2015[Jan]; 94
(4
): e496
PMID25634200
show ga
Splanchnic vein thrombosis (SVT) refers to Budd-Chiari syndrome (BCS) and portal
vein system thrombosis (PVST). Current practice guidelines have recommended the
routine screening for antiphospholipid antibodies (APAs) in patients with SVT. A
systematic review and meta-analysis of observational studies was performed to
explore the association between APAs and SVT. The PubMed, EMBASE, and
ScienceDirect databases were searched for all relevant papers, in which the
prevalence of positive APAs or levels of APAs should be compared between BCS or
noncirrhotic PVST patients versus healthy controls, or between cirrhotic patients
with portal vein thrombosis (PVT) versus those without PVT. Fourteen studies were
eligible. Only 1 study evaluated the role of APAs in BCS patients and found that
positive immunoglobulin (Ig) G anticardiolipin antibody (aCL) was more frequently
observed in BCS patients than in healthy controls; however, the associations of
other APAs with BCS were not evaluated. Positive IgG aCL was more frequently
observed in noncirrhotic patients with PVST than in healthy controls; however,
other APAs, such as IgM aCL, lupus anticoagulants (LAs), anti-?2-glycoprotein-I
antibody (a?2GPI), and a?2GPI-oxidized low-density lipoprotein antibody (ox-LDL)
were not associated with noncirrhotic PVST. Positive unclassified aCL was more
frequently observed in cirrhotic patients with PVT than in those without PVT;
however, the association of IgG aCL and IgM aCL with the development of PVT in
liver cirrhosis remained inconsistent among studies. The risk of BCS and
noncirrhotic PVST might be increased by positive IgG aCL but not IgM aCL, LA,
a?2GPI, or a?2GPI ox-LDL. However, the evidence regarding APAs in BCS originated
from only 1 study. The association between APAs and PVT in liver cirrhosis was
unclear.
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