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2015 ; 94
(34
): e1392
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gab.com Text
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English Wikipedia
Primary Pulmonary Synovial Sarcoma in a Tertiary Referral Center: Clinical
Characteristics, CT, and 18F-FDG PET Findings, With Pathologic Correlations
#MMPMID26313782
Kim GH
; Kim MY
; Koo HJ
; Song JS
; Choi CM
Medicine (Baltimore)
2015[Aug]; 94
(34
): e1392
PMID26313782
show ga
The purpose of this study was to describe the patient characteristics, computed
tomography (CT) and F-fluorodeoxyglucose positron emission tomography (FDG PET)
findings, and clinical outcomes of primary pulmonary synovial sarcoma (PPSS),
together with their pathologic correlations. The medical records of 14 patients
with pathologically proven PPSS in a tertiary hospital from January 1997 to
December 2014 were retrospectively reviewed. The CT findings were evaluated. The
maximum standardized uptake value (maxSUV) of the tumors was obtained, and
clinical outcomes with respect to tumor recurrence and mortality were assessed by
Kaplan-Meier analysis. The median tumor size was 10.2?cm and the most common
anatomic location was the lung followed by the pleura/chest wall and mediastinum.
Most of the tumors appeared as single lesions and had circumscribed margins. All
the cases showed heterogeneous enhancement with necrotic or cystic portions, and
intratumoral vessels were frequently seen. Half of the tumors had intratumoral
calcifications, and tumor rupture, pleural/chest wall extension, and pleural
effusion occurred frequently. However, lymph node enlargement was rare. The
median maxSUV of the tumors was 4.35. Patient outcomes with respect to tumor
recurrence (n?=?8, 57.1%) and death (n?=?3, 21.4%) were poor despite their young
age, and the mean follow-up period was 28.5 months.In conclusion, PPSS usually
occurs in young adults, generally in the lung, presents as a large, circumscribed
mass, and tumor rupture or extension of the pleura/chest wall may occur. The
tumors often contain calcifications and vessels; they may exhibit triple
attenuation on enhanced CT images, and clinical outcomes are poor.