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10.1097/MD.0000000000001392

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C4602937!4602937 !26313782
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suck abstract from ncbi


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pmid26313782
      Medicine+(Baltimore) 2015 ; 94 (34 ): e1392
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  • Primary Pulmonary Synovial Sarcoma in a Tertiary Referral Center: Clinical Characteristics, CT, and 18F-FDG PET Findings, With Pathologic Correlations #MMPMID26313782
  • Kim GH ; Kim MY ; Koo HJ ; Song JS ; Choi CM
  • Medicine (Baltimore) 2015[Aug]; 94 (34 ): e1392 PMID26313782 show ga
  • The purpose of this study was to describe the patient characteristics, computed tomography (CT) and F-fluorodeoxyglucose positron emission tomography (FDG PET) findings, and clinical outcomes of primary pulmonary synovial sarcoma (PPSS), together with their pathologic correlations. The medical records of 14 patients with pathologically proven PPSS in a tertiary hospital from January 1997 to December 2014 were retrospectively reviewed. The CT findings were evaluated. The maximum standardized uptake value (maxSUV) of the tumors was obtained, and clinical outcomes with respect to tumor recurrence and mortality were assessed by Kaplan-Meier analysis. The median tumor size was 10.2?cm and the most common anatomic location was the lung followed by the pleura/chest wall and mediastinum. Most of the tumors appeared as single lesions and had circumscribed margins. All the cases showed heterogeneous enhancement with necrotic or cystic portions, and intratumoral vessels were frequently seen. Half of the tumors had intratumoral calcifications, and tumor rupture, pleural/chest wall extension, and pleural effusion occurred frequently. However, lymph node enlargement was rare. The median maxSUV of the tumors was 4.35. Patient outcomes with respect to tumor recurrence (n?=?8, 57.1%) and death (n?=?3, 21.4%) were poor despite their young age, and the mean follow-up period was 28.5 months.In conclusion, PPSS usually occurs in young adults, generally in the lung, presents as a large, circumscribed mass, and tumor rupture or extension of the pleura/chest wall may occur. The tumors often contain calcifications and vessels; they may exhibit triple attenuation on enhanced CT images, and clinical outcomes are poor.
  • |*Lung Neoplasms/epidemiology/pathology/therapy [MESH]
  • |*Sarcoma, Synovial/epidemiology/pathology/therapy [MESH]
  • |Adult [MESH]
  • |Biopsy/methods [MESH]
  • |Chemoradiotherapy/methods [MESH]
  • |Female [MESH]
  • |Fluorodeoxyglucose F18 [MESH]
  • |Humans [MESH]
  • |Kaplan-Meier Estimate [MESH]
  • |Lung/pathology/surgery [MESH]
  • |Male [MESH]
  • |Neoplasm Recurrence, Local/diagnosis [MESH]
  • |Pneumonectomy/methods [MESH]
  • |Positron-Emission Tomography/methods [MESH]
  • |Radiopharmaceuticals [MESH]
  • |Republic of Korea/epidemiology [MESH]
  • |Retrospective Studies [MESH]
  • |Tertiary Care Centers/statistics & numerical data [MESH]


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