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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(34
): e1436
Nephropedia Template TP
gab.com Text
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Intensive Periodontal Treatment Reduces Risk of Infection-Related Hospitalization
in Hemodialysis Population: A Nationwide Population-Based Cohort Study
#MMPMID26313800
Huang ST
; Lin CL
; Yu TM
; Wu MJ
; Kao CH
Medicine (Baltimore)
2015[Aug]; 94
(34
): e1436
PMID26313800
show ga
Periodontal disease (PD) is prevalent and correlated with malnutrition and
inflammation in patients on hemodialysis (HD). Periodontal therapy improves
systemic inflammatory and nutritional markers in HD population. The relationship
between intensive PD therapy and clinical infectious outcomes in patients on HD
remains unclear.In total, 4451 patients who underwent HD and intensive PD
treatment between January 1, 1998 and December 31, 2010 were selected from the
National Health Insurance Research Database as the case cohort. The comparison
cohort was selected by matching a patient without PD with each PD treated patient
at a 1:1 ratio according to a propensity score. The rates of hospitalizations for
infectious diseases for both cohorts were analyzed and compared.Compared with the
comparison cohort, the hazard ratio (HR) of hospitalization for overall
infectious diseases was 0.72 (95% confidence interval [CI]?=?0.66-0.78,
P?0.001) for the intensive PD treatment cohort. The intensive PD treated cohort
had a significantly lower risk of acute and subacute infective endocarditis
(HR?=?0.54, 95% CI?=?0.35-0.84, P?0.01), pneumonia (HR?=?0.71, 95%
CI?=?0.65-0.78, P?0.001), and osteomyelitis (HR?=?0.77, 95% CI?=?0.62-0.96,
P?0.05) than did the comparison cohort.The intensive PD treatment of patients
with HD was associated with reduced risks of overall infectious diseases, acute
and subacute infective endocarditis, pneumonia, and osteomyelitis. Our study
concurs the role of a conventional intervention in enhancing infectious diseases
outcomes.
|*Hospitalization
[MESH]
|*Renal Dialysis
[MESH]
|Aged
[MESH]
|Bacterial Infections/*etiology/*prevention & control
[MESH]