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10.1097/MD.0000000000001422 http://scihub22266oqcxt.onion/10.1097/MD.0000000000001422 C4602917!4602917!26313793     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Medicine+(Baltimore) 2015 ; 94 (34): ä Nephropedia Template TP {{tp|p=26313793|t=2015. Clinical and Genetic Factors Associated With Thiazide-Induced Hyponatremia |pdf=|usr=}}{{26313793}} gab.com Text Clinical and Genetic Factors Associated With Thiazide-Induced Hyponatremia JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=26313793 #FOAvip Thiazide diuretics are associated with an increased risk of hyponatremia. The aim of this study was to investigate possible predictors of thiazide-induced hyponatremia.A total of 48 patients admitted to the ward or to the emergency department due to severe thiazide-induced hyponatremia (Na?<?125?mmol/L) were enrolled in our study as the case group. Another 211 hypertensive patients with normal sodium levels after treatment with thiazide diuretics were selected as the control group. Twelve tag single nucleotide polymorphism markers were selected from the Potassium Channel, Inwardly Rectifying Subfamily J, Member 1 (KCNJ1) gene: rs1231254, rs2238009, rs1148058, rs675482, rs673614, rs12795437, rs2855800, rs2509585, rs3016774, rs881333, rs4529890, and rs7116606. Clinical and genetic parameters between patients with thiazide-induced hyponatremia and the control group were compared. Logistic regression was used to analyze data.The patients with thiazide-induced hyponatremia were older (P?<?0.001), predominantly female (P?=?0.008), had a lower mean body mass index (BMI) (P?<?0.001), and more commonly used angiotensin II receptor antagonist (P?<?0.001) and spironolactone (P?=?0.007) compared with the control groups. Analysis with multivariate logistic regression revealed that age (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.08?1.19, P?<?0.001), female gender (OR, 4.49; 95% CI, 1.54?13.11, P?=?0.006), BMI (OR, 0.80; 95% CI, 0.69?0.93, P?=?0.003), and KCNJ1 rs2509585?C/T or T/T polymorphisms (OR, 5.75; 95% CI, 1.25?26.45, P?=?0.03) were independent predictors for thiazide-induced hyponatremia.Older female patients with lower BMIs and KCNJ1 rs2509585?C/T or T/T polymorphisms were more likely to develop thiazide-induced hyponatremia. Twit Text FOAVip Clinical and Genetic Factors Associated With Thiazide-Induced Hyponatremia ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=26313793 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26313793 #FOAvip English Wikipedia <ref>{{Cite pmid|26313793}}</ref> Clinical and Genetic Factors Associated With Thiazide-Induced Hyponatremia #MMPMID26313793 Huang CC; Chung CM; Hung SI; Pan WH; Leu HB; Huang PH; Chiu CC; Lin LY; Lin CC; Yang CY; Li Sy; Chen YC; Wu TC; Lin SJ; Chen JW Medicine (Baltimore) 2015[Aug]; 94 (34): ä PMID26313793show ga Thiazide diuretics are associated with an increased risk of hyponatremia. The aim of this study was to investigate possible predictors of thiazide-induced hyponatremia.A total of 48 patients admitted to the ward or to the emergency department due to severe thiazide-induced hyponatremia (Na? äClinical and Genetic Factors Associated With Thiazide-Induced Hyponatr(epmc).pdf DeepDyve Pubget Overpricing