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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(1
): e267
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Comprehensive description of clinical characteristics of a large systemic lupus
erythematosus cohort from the Spanish Rheumatology Society Lupus Registry
(RELESSER) with emphasis on complete versus incomplete lupus differences
#MMPMID25569641
Rúa-Figueroa Í
; Richi P
; López-Longo FJ
; Galindo M
; Calvo-Alén J
; Olivé-Marqués A
; Loza-Santamaría E
; Vicente SP
; Erausquin C
; Tomero E
; Horcada L
; Uriarte E
; Sánchez-Atrio A
; Rosas J
; Montilla C
; Fernández-Nebro A
; Rodríguez-Gómez M
; Vela P
; Blanco R
; Freire M
; Silva L
; Díez-Álvarez E
; Ibáñez-Barceló M
; Zea A
; Narváez J
; Martínez-Taboada V
; Marenco JL
; de Castro MF
; Fernández-Berrizbeitia O
; Hernández-Beriain JÁ
; Gantes M
; Hernández-Cruz B
; Pérez-Venegas JJ
; Pecondón Á
; Marras C
; Carreira P
; Bonilla G
; Torrente V
; Castellví I
; Alegre J
; Moreno M
; Raya E
; de la Peña PG
; Vázquez T
; Aguirre Á
; Quevedo V
; Pego-Reigosa JM
Medicine (Baltimore)
2015[Jan]; 94
(1
): e267
PMID25569641
show ga
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by
multiple organ involvement and pronounced racial and ethnic heterogeneity. The
aims of the present work were (1) to describe the cumulative clinical
characteristics of those patients included in the Spanish Rheumatology Society
SLE Registry (RELESSER), focusing on the differences between patients who
fulfilled the 1997 ACR-SLE criteria versus those with less than 4 criteria
(hereafter designated as incomplete SLE (iSLE)) and (2) to compare SLE patient
characteristics with those documented in other multicentric SLE
registries.RELESSER is a multicenter hospital-based registry, with a collection
of data from a large, representative sample of adult patients with SLE (1997 ACR
criteria) seen at Spanish rheumatology departments. The registry includes
demographic data, comprehensive descriptions of clinical manifestations, as well
as information about disease activity and severity, cumulative damage,
comorbidities, treatments and mortality, using variables with highly standardized
definitions.A total of 4.024 SLE patients (91% with ?4 ACR criteria) were
included. Ninety percent were women with a mean age at diagnosis of 35.4 years
and a median duration of disease of 11.0 years. As expected, most SLE
manifestations were more frequent in SLE patients than in iSLE ones and every one
of the ACR criteria was also associated with SLE condition; this was particularly
true of malar rash, oral ulcers and renal disorder. The analysis-adjusted by
gender, age at diagnosis, and disease duration-revealed that higher disease
activity, damage and SLE severity index are associated with SLE [OR: 1.14; 95%
CI: 1.08-1.20 (P?0.001); 1.29; 95% CI: 1.15-1.44 (P?0.001); and 2.10; 95% CI:
1.83-2.42 (P?0.001), respectively]. These results support the hypothesis that
iSLE behaves as a relative stable and mild disease. SLE patients from the
RELESSER register do not appear to differ substantially from other Caucasian
populations and although activity [median SELENA-SLEDA: 2 (IQ: 0-4)], damage
[median SLICC/ACR/DI: 1 (IQ: 0-2)], and severity [median KATZ index: 2 (IQ: 1-3)]
scores were low, 1 of every 4 deaths was due to SLE activity.RELESSER represents
the largest European SLE registry established to date, providing comprehensive,
reliable and updated information on SLE in the southern European population.