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2014 ; 93
(27
): e225
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Risk factors for lymphatic metastasis of malignant bone and soft-tissue tumors: a
retrospective cohort study of 242 patients
#MMPMID25501082
Yanagawa T
; Saito K
; Takagishi K
Medicine (Baltimore)
2014[Dec]; 93
(27
): e225
PMID25501082
show ga
Metastasis to the lymph nodes is relatively rare in malignant bone and
soft-tissue tumors, and its risk factors remains unknown, except for tumors of
the lymphogenous histotype, including rhabdomyosarcoma, epithelioid sarcoma, and
clear cell sarcoma. The purpose of this study was to identify the risk factors
for lymph node metastasis of malignant bone and soft-tissue tumors. We
retrospectively reviewed 242 patients with malignant bone and soft-tissue tumors.
The predictors of interest for the risk of lymph node metastasis included age,
sex, histopathological diagnosis, location(s) of the primary tumor(s), local
recurrence, residual tumor(s), and the size of the primary tumors. To identify
the risk factors for lymph node metastasis, Cox regression analyses were
performed. Among the 242 patients with malignant bone and soft-tissue tumors in
the current study, 60, 29, and 28 were detected to have lung, lymph node, and
bone metastases, respectively. In the univariate analyses, the lymphogenous
histotype and a primary tumor invading the subcutis were the risk factors for
lymph node metastasis. In the multivariate analysis, the lymphogenous histotype
(P < 0.01) and a primary tumor in the subcutis (P < 0.01) remained significantly
associated with a higher risk of lymph node metastasis with 5.15 and 3.48 of
hazard ratios, respectively. Lymph node metastasis was detected in malignant bone
and soft-tissue tumors more frequently than that has been previously reported,
and the risk factors for lymph node metastasis were the lymphogenous histotype
and primary tumors invading the subcutis.