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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2014 ; 93
(27
): e195
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gab.com Text
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Could early rheumatoid arthritis resolve after periodontitis treatment only?:
case report and review of the literature
#MMPMID25501069
Salemi S
; Biondo MI
; Fiorentino C
; Argento G
; Paolantonio M
; Di Murro C
; Malagnino VA
; Canzoni M
; Diamanti AP
; D'Amelio R
Medicine (Baltimore)
2014[Dec]; 93
(27
): e195
PMID25501069
show ga
Rheumatoid arthritis (RA) is an immune-mediated polyarthritis; currently no
pathogenic agent has been identified as a disease trigger. A patient with RA,
presumably caused by periodontal infection, whose remission has been observed
after periodontitis treatment in absence of specific RA therapy, is reported here
for the first time, to our knowledge. A 61-year-old male patient presented
migrant arthritis associated with antibodies against citrullinated protein
antigens positivity. The clinical features allowed to make RA diagnosis according
to the 2010 European League against Rheumatism/American College of Rheumatology
RA classification criteria. X-ray of the second upper molar showed chronic apical
periodontitis. After its treatment, arthritis remission has been observed in the
absence of specific RA therapy. It has been suggested that periodontitis may have
a trigger role in RA pathogenesis. This could be explained by the enzymatic
action of Porphyromonas gingivalis, probably leading to break tolerance to
collagen. The identification and subsequent treatment of periodontitis should
therefore be considered pivotal in RA prophylaxis and management.