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2015 ; 94
(6
): e487
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Cytoarchitectural and functional abnormalities of the inferior colliculus in
sudden unexplained perinatal death
#MMPMID25674737
Lavezzi AM
; Pusiol T
; Matturri L
Medicine (Baltimore)
2015[Feb]; 94
(6
): e487
PMID25674737
show ga
The inferior colliculus is a mesencephalic structure endowed with serotonergic
fibers that plays an important role in the processing of acoustic information.
The implication of the neuromodulator serotonin also in the aetiology of sudden
unexplained fetal and infant death syndromes and the demonstration in these
pathologies of developmental alterations of the superior olivary complex (SOC), a
group of pontine nuclei likewise involved in hearing, prompted us to investigate
whether the inferior colliculus may somehow contribute to the pathogenetic
mechanism of unexplained perinatal death. Therefore, we performed in a wide set
of fetuses and infants, aged from 33 gestational weeks to 7 postnatal months and
died of both known and unknown cause, an in-depth anatomopathological analysis of
the brainstem, particularly of the midbrain. Peculiar neuroanatomical and
functional abnormalities of the inferior colliculus, such as
hypoplasia/structural disarrangement and immunonegativity or poor positivity of
serotonin, were exclusively found in sudden death victims, and not in controls.
In addition, these alterations were frequently related to dysgenesis of connected
structures, precisely the raphé nuclei and the superior olivary complex, and to
nicotine absorption in pregnancy. We propose, on the basis of these results, the
involvement of the inferior colliculus in more important functions than those
related to hearing, as breathing and, more extensively, all the vital activities,
and then in pathological conditions underlying a sudden death in vulnerable
periods of the autonomic nervous system development, particularly associated to
harmful risk factors as cigarette smoking.
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