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10.1097/MD.0000000000000480

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C4602713!4602713 !25654389
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suck abstract from ncbi


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pmid25654389
      Medicine+(Baltimore) 2015 ; 94 (5 ): e480
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  • Successful treatment of fibrosing cholestatic hepatitis following kidney transplantation with allogeneic hematopoietic stem cell transplantation: a case report #MMPMID25654389
  • Li DL ; Fang J ; Zheng Z ; Wu W ; Wu Z
  • Medicine (Baltimore) 2015[Feb]; 94 (5 ): e480 PMID25654389 show ga
  • Fibrosing cholestatic hepatitis (FCH) is an uncommon complication of renal transplantation and usually associated with hepatitis B and C viral infection. Without treatment, the prognosis is usually fatal within weeks of onset. There was rarely report with successful treatment intervention. This case report describes a uremic patient with HCV infection who developed a fatal form of FCH after kidney transplantation. This is the first reported successful case with allogeneic hematopoietic stem cell transplantation (AHSCT) without ablative conditioning. A dramatic virologic and clinical improvement was observed in this post-transplantation patient. But no adverse events related to AHSCT were observed. The patient returned to work full-time at 10 months of hospitalization and is still in good health by now. Serum HCV RNA gradually decreased from 2.5?×?10?(6) Copies/mL at day 1 to 3.2?×?10?(4) Copies/mL at day 98 and became negative (<400? Copies/mL) at day 126 of hospitalization and remains negative at the last available assessment. Our report suggests that allogeneic HSCT may have a therapeutic role in FCH.
  • |Cholestasis, Intrahepatic/*etiology/pathology/*therapy [MESH]
  • |Fibrosis [MESH]
  • |Hematopoietic Stem Cell Transplantation/*methods [MESH]
  • |Hepatitis C/epidemiology [MESH]
  • |Humans [MESH]
  • |Immunosuppressive Agents/administration & dosage [MESH]
  • |Kidney Transplantation/*adverse effects [MESH]
  • |Male [MESH]


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