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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(16
): e667
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Primary Sjögren syndrome in Han Chinese: clinical and immunological
characteristics of 483 patients
#MMPMID25906094
Zhao Y
; Li Y
; Wang L
; Li XF
; Huang CB
; Wang GC
; Zhang XW
; Zhang ZL
; Zhang X
; Xiao WG
; Dai L
; Wang YF
; Hu SX
; Li HB
; Gong L
; Liu B
; Sun LY
; Zhang MJ
; Zhang X
; Li YZ
; Du DS
; Zhang SH
; Sun YY
; Zhang FC
Medicine (Baltimore)
2015[Apr]; 94
(16
): e667
PMID25906094
show ga
The epidemiological characteristics of Sjögren syndrome (SS) are significantly
varied in different countries. We conducted the present study to survey the
epidemiological characteristics of primary SS in China. We recruited 483 primary
SS patients from 16 Chinese medical centers nationwide from January 2009 to
November 2011 and assessed salivary and lacrimal gland dysfunction, organ
involvement, and autoimmunity in these patients. The cohort included 456 women
and 27 men (ratio, 17:1; mean age at onset, 42?±?11 years; median age at
diagnosis, 49 years; range, 41-56 years). Male patients showed a lower frequency
of xerophthalmia (37.0% vs 60.7%) and a higher frequency of arthritis (40.7% vs
16.4%). Young-onset patients showed a higher frequency of low C3 levels (57.7% vs
36.3%) and pancytopenia (22.2% vs 8.8%). Patients with systemic involvement had a
higher frequency of immunoglobulin A (IgA) (39.4% vs 22.5%) and immunoglobulin M
(IgM) (12.4% vs 37.9%). Patients with pulmonary involvement had a higher parotid
enlargement (21.4% vs 10.2%), purpura (12.1% vs 5.7%) and higher anti-La/SS-B
(61.7% vs 41.8%), immunoglobulin G (IgG) (80.7% vs 64.6%) and IgA (48.9% vs
30.6%) levels. Patients with anti-Ro/SSA antibodies had more frequent exocrine
gland symptoms and some extraglandular symptoms and immunological alterations.
Compared with previous studies performed in other countries, SS patients in China
showed particular clinical manifestation, systemic involvement, and immunological
alterations.